U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DUN1 serine/threonine protein kinase DUN1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851457, updated on 28-Oct-2024

Summary

Official Symbol
DUN1
Official Full Name
serine/threonine protein kinase DUN1
Primary source
SGD:S000002259
Locus tag
YDL101C
See related
AllianceGenome:SGD:S000002259; FungiDB:YDL101C; VEuPathDB:YDL101C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein serine/threonine kinase activity. Involved in DNA damage checkpoint signaling. Acts upstream of or within double-strand break repair via nonhomologous end joining and replication fork processing. Located in nucleus. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast cancer (multiple); colorectal cancer; osteosarcoma; and prostate cancer. Orthologous to human CHEK2 (checkpoint kinase 2). [provided by Alliance of Genome Resources, Oct 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See DUN1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (280307..281848, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene UDP-N-acetylglucosamine diphosphorylase Neighboring gene DNA-directed DNA polymerase delta POL3 Neighboring gene guanine nucleotide exchange factor GET3 Neighboring gene Bug1p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity HDA PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine protein kinase DUN1
NP_010182.1
  • Cell-cycle checkpoint S/T protein kinase; required for transient G2/M arrest after DNA damage, damage-induced transcription, and nuclear-to-cytoplasmic redistribution of Rnr2p-Rnr4p after genotoxic stress and iron deprivation; phosphorylates repair protein Rad55p, transcriptional repressor Sml1p, superoxide dismutase, and ribonucleotide reductase inhibitors Crt1p and Dif1p; functions in the Mec1p pathway to regulate dNTP pools and telomere length; postreplicative repair role

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    280307..281848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180160.1NP_010182.1  TPA: serine/threonine protein kinase DUN1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010182.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRP9, P39009
    UniProtKB/TrEMBL
    A6ZXM8
    Conserved Domains (2) summary
    cd00060
    Location:36136
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd05117
    Location:199479
    STKc_CAMK; The catalytic domain of CAMK family Serine/Threonine Kinases