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RRP42 exosome non-catalytic core subunit RRP42 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851447, updated on 2-Nov-2024

Summary

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Official Symbol
RRP42
Official Full Name
exosome non-catalytic core subunit RRP42
Primary source
SGD:S000002269
Locus tag
YDL111C
See related
AllianceGenome:SGD:S000002269; FungiDB:YDL111C; VEuPathDB:YDL111C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable mRNA 3'-UTR AU-rich region binding activity. Involved in TRAMP-dependent tRNA surveillance pathway; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and rRNA catabolic process. Part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Orthologous to human EXOSC7 (exosome component 7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RRP42 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (263313..264110, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Atg20p Neighboring gene tRNA (guanosine(18)-2'-O)-methyltransferase Neighboring gene Tma17p Neighboring gene putative lipase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The archaeal exosome core is a hexameric ring structure with three catalytic subunits. Lorentzen E, et al. Nat Struct Mol Biol, 2005 Jul. PMID 15951817
  2. The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases. Mitchell P, et al. Cell, 1997 Nov 14. PMID 9390555
  3. Subunit architecture of multimeric complexes isolated directly from cells. Hernández H, et al. EMBO Rep, 2006 Jun. PMID 16729021, Free PMC Article
  4. Visualization of distinct substrate-recruitment pathways in the yeast exosome by EM. Liu JJ, et al. Nat Struct Mol Biol, 2014 Jan. PMID 24336220, Free PMC Article
  5. Architecture of the yeast Rrp44 exosome complex suggests routes of RNA recruitment for 3' end processing. Wang HW, et al. Proc Natl Acad Sci U S A, 2007 Oct 23. PMID 17942686, Free PMC Article

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR AU-rich region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in TRAMP-dependent tRNA surveillance pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in TRAMP-dependent tRNA surveillance pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in TRAMP-dependent tRNA surveillance pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in U1 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in U4 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in U5 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
Inferred from Electronic Annotation
more info
  
involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear mRNA surveillance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear polyadenylation-dependent rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytoplasmic exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic exosome (RNase complex) IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytoplasmic exosome (RNase complex) IEA
Inferred from Electronic Annotation
more info
  
part_of exosome (RNase complex) IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear exosome (RNase complex) IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear exosome (RNase complex) IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
exosome non-catalytic core subunit RRP42
NP_010172.1
  • Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    263313..264110 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180170.1 → NP_010172.1  TPA: exosome non-catalytic core subunit RRP42 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010172.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRN9, Q12277
    UniProtKB/TrEMBL
    A6ZXL8, B3LH02, B5VFF8, C7GJK5, C8Z6J3, G2WC51, N1P5W4
    Conserved Domains (1) summary
    cd11367
    Location:2 → 264
    RNase_PH_RRP42; RRP42 subunit of eukaryotic exosome
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12277.1

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