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UBP1 ubiquitin-specific protease UBP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851435, updated on 2-Nov-2024

Summary

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Official Symbol
UBP1
Official Full Name
ubiquitin-specific protease UBP1
Primary source
SGD:S000002280
Locus tag
YDL122W
See related
AllianceGenome:SGD:S000002280; FungiDB:YDL122W; VEuPathDB:YDL122W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables cysteine-type deubiquitinase activity. Involved in protein deubiquitination. Located in endoplasmic reticulum. Is active in endoplasmic reticulum membrane. Orthologous to human USP30 (ubiquitin specific peptidase 30). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See UBP1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (242552..244981)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase superfamily protein Neighboring gene Sna4p Neighboring gene Exp1p Neighboring gene ferroxidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of yeast deubiquitination enzyme UBP1 analogues in E. coli. Wojtowicz A, et al. Microb Cell Fact, 2005 May 30. PMID 15924623, Free PMC Article
  2. A ubiquitin-protein ligase (E3) mutation of Saccharomyces cerevisiae suppressed by co-overexpression of two ubiquitin-specific processing proteases. Kanda T. Genes Genet Syst, 1996 Apr. PMID 8752868
  3. Characterization of ubiquitin C-terminal hydrolase 1 (YUH1) from Saccharomyces cerevisiae expressed in recombinant Escherichia coli. Yu HA, et al. Protein Expr Purif, 2007 Nov. PMID 17709260
  4. Cloning and functional analysis of the ubiquitin-specific protease gene UBP1 of Saccharomyces cerevisiae. Tobias JW, et al. J Biol Chem, 1991 Jun 25. PMID 2050695
  5. The deubiquitinating enzyme Ubp1 affects sorting of the ATP-binding cassette-transporter Ste6 in the endocytic pathway. Schmitz C, et al. Mol Biol Cell, 2005 Mar. PMID 15635103, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ubp1 has a role in sorting the ATP-binding cassette-transporter Ste6 in the endocytic pathway
    Title: The deubiquitinating enzyme Ubp1 affects sorting of the ATP-binding cassette-transporter Ste6 in the endocytic pathway.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin-specific protease UBP1
NP_010161.1
  • Ubiquitin-specific protease; removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    242552..244981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180181.1 → NP_010161.1  TPA: ubiquitin-specific protease UBP1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010161.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRM8, P25037, Q07543
    UniProtKB/TrEMBL
    C7GJJ4, N1PA89
    Conserved Domains (2) summary
    cd02662
    Location:102 → 736
    Peptidase_C19F; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:101 → 293
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25037.2

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