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CDC53 cullin CDC53 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851424, updated on 3-Nov-2024

Summary

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Official Symbol
CDC53
Official Full Name
cullin CDC53
Primary source
SGD:S000002290
Locus tag
YDL132W
See related
AllianceGenome:SGD:S000002290; FungiDB:YDL132W; VEuPathDB:YDL132W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables DNA replication origin binding activity and protein-macromolecule adaptor activity. Contributes to ubiquitin protein ligase activity. Involved in G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; and SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Part of SCF ubiquitin ligase complex. Orthologous to several human genes including CUL1 (cullin 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CDC53 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (224304..226751)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L41B Neighboring gene Srf1p Neighboring gene homocitrate synthase LYS21 Neighboring gene ATPase-binding protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Null mutation of AtCUL1 causes arrest in early embryogenesis in Arabidopsis. Shen WH, et al. Mol Biol Cell, 2002 Jun. PMID 12058059, Free PMC Article
  2. An auxin-based degron system for the rapid depletion of proteins in nonplant cells. Nishimura K, et al. Nat Methods, 2009 Dec. PMID 19915560
  3. DH334, a beta-carboline anti-cancer drug, inhibits the CDK activity of budding yeast. Li Y, et al. Cancer Biol Ther, 2007 Aug. PMID 17622795
  4. Skp1p and the F-box protein Rcy1p form a non-SCF complex involved in recycling of the SNARE Snc1p in yeast. Galan JM, et al. Mol Cell Biol, 2001 May. PMID 11287615, Free PMC Article
  5. Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins. Mathias N, et al. Mol Cell Biol, 1996 Dec. PMID 8943317, Free PMC Article

See all (152) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This ubiquitylation and degradation pathway acts on Met30 that is dissociated from Skp1. Unexpectedly, this pathway required the cullin component Cdc53/Cul1 but was independent of the other central SCF component Skp1
    Title: Skp1 Independent Function of Cdc53/Cul1 in F-box Protein Homeostasis.
  2. A dual E3 mechanism for Rub1 ligation to Cdc53.
    Title: A dual E3 mechanism for Rub1 ligation to Cdc53.
  3. binding of substrate-specific adaptors triggers release of Cand1/Lag2, whereas subsequent neddylation of the cullin facilitates the removal and prevents re-association of Lag2/Cand1
    Title: Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae.
  4. The binding site for Dcn1 on Cdc53 is located approximately 18 A from the site of neddylation.
    Title: Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation.
  5. the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination
    Title: Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA replication origin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-macromolecule adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein-macromolecule adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in G2/M transition of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in macromolecule catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SCF ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
part_of cullin-RING ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cullin CDC53
NP_010150.1
  • Cullin; structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation; human homolog CUL1 can complement yeast cdc53 null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    224304..226751
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180191.1 → NP_010150.1  TPA: cullin CDC53 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010150.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRL7, Q12018
    UniProtKB/TrEMBL
    G2WC29, N1P5J1
    Conserved Domains (1) summary
    COG5647
    Location:7 → 815
    COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12018.1

Gene LinkOut

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