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RGT2 glucose sensor [ Saccharomyces cerevisiae S288C ]

Gene ID: 851417, updated on 2-Nov-2024

Summary

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Official Symbol
RGT2
Official Full Name
glucose sensor
Primary source
SGD:S000002297
Locus tag
YDL138W
See related
AllianceGenome:SGD:S000002297; FungiDB:YDL138W; VEuPathDB:YDL138W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables D-glucose binding activity. Involved in glucose mediated signaling pathway. Located in plasma membrane. Orthologous to human SLC2A6 (solute carrier family 2 member 6) and SLC2A8 (solute carrier family 2 member 8). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RGT2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (213351..215642)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase II core subunit RPO21 Neighboring gene Scm3p Neighboring gene Arf family GTPase ARF2 Neighboring gene ribosomal 60S subunit protein L35B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two glucose sensing/signaling pathways stimulate glucose-induced inactivation of maltose permease in Saccharomyces. Jiang H, et al. Mol Biol Cell, 1997 Jul. PMID 9243508, Free PMC Article
  2. Glucose regulation of the paralogous glucose sensing receptors Rgt2 and Snf3 of the yeast Saccharomyces cerevisiae. Kim JH, et al. Biochim Biophys Acta Gen Subj, 2021 Jun. PMID 33617932
  3. Glucose sensing and signaling by two glucose receptors in the yeast Saccharomyces cerevisiae. Ozcan S, et al. EMBO J, 1998 May 1. PMID 9564039, Free PMC Article
  4. Genetic Analysis of Signal Generation by the Rgt2 Glucose Sensor of Saccharomyces cerevisiae. Scharff-Poulsen P, et al. G3 (Bethesda), 2018 Jul 31. PMID 29954842, Free PMC Article
  5. Cellobiose Consumption Uncouples Extracellular Glucose Sensing and Glucose Metabolism in Saccharomyces cerevisiae. Chomvong K, et al. mBio, 2017 Aug 8. PMID 28790206, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Multiple roles for the cytoplasmic C-terminal domains of the yeast cell surface receptors Rgt2 and Snf3 in glucose sensing and signaling.
    Title: Multiple roles for the cytoplasmic C-terminal domains of the yeast cell surface receptors Rgt2 and Snf3 in glucose sensing and signaling.
  2. RGT2 constitutive mutations alter evolutionarily-conserved amino acids in the transmembrane spanning regions of Rgt2. They cause Rgt2 to adopt inward-facing or occluded conformations that generate the glucose signal.
    Title: Genetic Analysis of Signal Generation by the Rgt2 Glucose Sensor of Saccharomyces cerevisiae.
  3. Rgt2 and Snf3 glucose sensors are primary targets of methylglyoxal, which causes degradation of the Rgt2 and Snf3.
    Title: The glucose metabolite methylglyoxal inhibits expression of the glucose transporter genes by inactivating the cell surface glucose sensors Rgt2 and Snf3 in yeast.
  4. Mth1 and Std1, which are downstream effectors of the Snf3/Rgt2 pathway, were required for viability through mitochondrial function but not fermentative metabolism
    Title: Disruption of Snf3/Rgt2 glucose sensors decreases lifespan and caloric restriction effectiveness through Mth1/Std1 by adjusting mitochondrial efficiency in yeast.
  5. RGT2-1 promotes ubiquitination and subsequent degradation of Mth1 and Std1 regardless of the presence of glucose.
    Title: Biochemical evidence for glucose-independent induction of HXT expression in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables D-glucose binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables carbohydrate:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
glucose sensor
NP_010143.1
  • Plasma membrane high glucose sensor that regulates glucose transport; low affinity sesnor that contains 12 predicted transmembrane segments and a long C-terminal tail required for hexose transporter induction; phosphorylation of the tail by Yck1p/Yck2p facilitates binding to the HXT co-repressors, Mth1p and Std1p; RGT2 has a paralog, SNF3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    213351..215642
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180198.1 → NP_010143.1  TPA: glucose sensor [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010143.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRL0, Q12300
    UniProtKB/TrEMBL
    G2WC23, N1P960
    Conserved Domains (1) summary
    TIGR00879
    Location:76 → 555
    SP; MFS transporter, sugar porter (SP) family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12300.1

Gene LinkOut

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