U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CDC36 CCR4-NOT core subunit CDC36 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851389, updated on 28-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
CDC36
Official Full Name
CCR4-NOT core subunit CDC36
Primary source
SGD:S000002324
Locus tag
YDL165W
See related
AllianceGenome:SGD:S000002324; FungiDB:YDL165W; VEuPathDB:YDL165W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DNA19; NOT2
Summary
Involved in several processes, including nuclear-transcribed mRNA catabolic process; positive regulation of transcription elongation by RNA polymerase II; and transcription elongation by RNA polymerase II. Located in cytoplasm and nucleus. Part of CCR4-NOT core complex. Orthologous to human CNOT2 (CCR4-NOT transcription complex subunit 2). [provided by Alliance of Genome Resources, Oct 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CDC36 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (164290..164865)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Nrp1p Neighboring gene nucleoside-triphosphatase Neighboring gene DNA ligase (ATP) CDC9 Neighboring gene epsin

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Nucleotide sequence of the yeast cell division cycle start genes CDC28, CDC36, CDC37, and CDC39, and a structural analysis of the predicted products. Ferguson J, et al. Nucleic Acids Res, 1986 Aug 26. PMID 3018676, Free PMC Article
  2. Cell-cycle mutations among the collection of Saccharomyces cerevisiae dna mutants. Evans DR, et al. FEMS Microbiol Lett, 1994 Feb 15. PMID 8150258
  3. CDC36 and CDC39 are negative elements in the signal transduction pathway of yeast. Neiman AM, et al. Cell Regul, 1990 Apr. PMID 2099190, Free PMC Article
  4. Mutations in cell division cycle genes CDC36 and CDC39 activate the Saccharomyces cerevisiae mating pheromone response pathway. de Barros Lopes M, et al. Mol Cell Biol, 1990 Jun. PMID 2111445, Free PMC Article
  5. A relationship between the yeast cell cycle genes CDC4 and CDC36 and the ets sequence of oncogenic virus E26. Peterson TA, et al. Nature, 1984 Jun 7-13. PMID 6374468

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in deadenylation-independent decapping of nuclear-transcribed mRNA IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear-transcribed mRNA poly(A) tail shortening IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nuclear-transcribed mRNA poly(A) tail shortening IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription elongation by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to pheromone triggering conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription elongation by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of CCR4-NOT core complex IEA
Inferred from Electronic Annotation
more info
  
part_of CCR4-NOT core complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
CCR4-NOT core subunit CDC36
NP_010116.1
  • Component of the CCR4-NOT core complex, involved in mRNA decapping; this complex has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs through deadenylation; basal transcription factor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    164290..164865
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180225.1 → NP_010116.1  TPA: CCR4-NOT core subunit CDC36 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010116.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRI6, P06100
    UniProtKB/TrEMBL
    A6ZXG5, B3LH51, B5VFA7, C7GL13, C8Z6D8, G2WBZ9, N1P951
    Conserved Domains (1) summary
    COG5601
    Location:5 → 191
    CDC36; General negative regulator of transcription subunit [Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06100.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools