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SFA1 bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851386, updated on 2-Nov-2024

Summary

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Official Symbol
SFA1
Official Full Name
bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase
Primary source
SGD:S000002327
Locus tag
YDL168W
See related
AllianceGenome:SGD:S000002327; FungiDB:YDL168W; VEuPathDB:YDL168W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ADH5
Summary
Enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity; alcohol dehydrogenase (NAD+) activity; and hydroxymethylfurfural reductase (NADH) activity. Involved in amino acid catabolic process to alcohol via Ehrlich pathway; formaldehyde catabolic process; and furaldehyde metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in AMED syndrome; alcohol dependence; asthma; late onset Parkinson's disease; and pancreatic cancer. Orthologous to several human genes including ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SFA1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (159604..160764)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Uga3p Neighboring gene Ugx2p Neighboring gene Nrp1p Neighboring gene nucleoside-triphosphatase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans. Liu L, et al. Nature, 2001 Mar 22. PMID 11260719
  2. Class III alcohol dehydrogenase from Saccharomyces cerevisiae: structural and enzymatic features differ toward the human/mammalian forms in a manner consistent with functional needs in formaldehyde detoxication. Fernández MR, et al. FEBS Lett, 1995 Aug 14. PMID 7649298
  3. Formaldehyde lacks genotoxicity in formaldehyde-hyperresistant strains of the yeast Saccharomyces cerevisiae. Wehner E, et al. Mutat Res, 1993 Sep. PMID 7689168
  4. Vector YFRp1 allows transformant selection in Saccharomyces cerevisiae via resistance to formaldehyde. Wehner EP, et al. Yeast, 1993 Jul. PMID 8368012
  5. A double residue substitution in the coenzyme-binding site accounts for the different kinetic properties between yeast and human formaldehyde dehydrogenases. Fernández MR, et al. J Biol Chem, 1999 Dec 31. PMID 10608852

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity IEA
Inferred from Electronic Annotation
more info
  
enables S-nitrosoglutathione reductase (NADH) activity IEA
Inferred from Electronic Annotation
more info
  
enables alcohol dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alcohol dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alcohol dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables alcohol dehydrogenase (NAD+) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydroxymethylfurfural reductase (NADH) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in amino acid catabolic process to alcohol via Ehrlich pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in formaldehyde catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in formaldehyde catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in formaldehyde catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in furaldehyde metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in small molecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase
NP_010113.1
  • Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    159604..160764
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180228.1 → NP_010113.1  TPA: bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010113.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRI3, P32771
    UniProtKB/TrEMBL
    A6ZXG2, C7GL16, N1PAL9
    Conserved Domains (1) summary
    cd08300
    Location:10 → 381
    alcohol_DH_class_III; class III alcohol dehydrogenases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32771.1

Gene LinkOut

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