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DLD1 D-lactate dehydrogenase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851380, updated on 14-Nov-2024

Summary

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Official Symbol
DLD1
Official Full Name
D-lactate dehydrogenase
Primary source
SGD:S000002333
Locus tag
YDL174C
See related
AllianceGenome:SGD:S000002333; FungiDB:YDL174C; VEuPathDB:YDL174C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables D-lactate dehydrogenase (cytochrome) activity. Involved in lactate catabolic process. Located in mitochondrial inner membrane. Orthologous to human LDHD (lactate dehydrogenase D). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See DLD1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (145826..147589, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Gid12p Neighboring gene TRAMP complex RNA-binding subunit Neighboring gene Par32p Neighboring gene glutamate synthase (NADH)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sorting of D-lactate dehydrogenase to the inner membrane of mitochondria. Analysis of topogenic signal and energetic requirements. Rojo EE, et al. J Biol Chem, 1998 Apr 3. PMID 9525904
  2. Isolation of the DLD gene of Saccharomyces cerevisiae encoding the mitochondrial enzyme D-lactate ferricytochrome c oxidoreductase. Lodi T, et al. Mol Gen Genet, 1993 Apr. PMID 8492799
  3. Kinetic activation of yeast mitochondrial D-lactate dehydrogenase by carboxylic acids. Mourier A, et al. Biochim Biophys Acta, 2008 Oct. PMID 18640090
  4. Kinetic properties of yeast D(-)-lactic cytochrome c reductase. NYGAARD AP. J Biol Chem, 1961 Jul. PMID 13729967
  5. Redirection of pyruvate flux toward desired metabolic pathways through substrate channeling between pyruvate kinase and pyruvate-converting enzymes in Saccharomyces cerevisiae. Kim S, et al. Sci Rep, 2016 Apr 7. PMID 27052099, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables D-lactate dehydrogenase (cytochrome) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-lactate dehydrogenase (cytochrome) activity IEA
Inferred from Electronic Annotation
more info
  
enables D-lactate dehydrogenase (cytochrome) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables D-lactate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on CH-OH group of donors IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in lactate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lactate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
D-lactate dehydrogenase
NP_010107.1
  • Major mitochondrial D-lactate dehydrogenase; oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    145826..147589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180234.1 → NP_010107.1  TPA: D-lactate dehydrogenase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010107.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRH8, P32891, Q12360
    UniProtKB/TrEMBL
    A6ZXF7, B3LH58, C7GL20, C8Z6D0, G2WBZ1, N1P5Q4
    Conserved Domains (1) summary
    PLN02805
    Location:49 → 574
    PLN02805; D-lactate dehydrogenase [cytochrome]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32891.2

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