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UFD2 ubiquitin-ubiquitin ligase UFD2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851337, updated on 2-Nov-2024

Summary

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Official Symbol
UFD2
Official Full Name
ubiquitin-ubiquitin ligase UFD2
Primary source
SGD:S000002349
Locus tag
YDL190C
See related
AllianceGenome:SGD:S000002349; FungiDB:YDL190C; VEuPathDB:YDL190C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ubiquitin-ubiquitin ligase activity. Involved in several processes, including cellular response to ethanol; protein K48-linked ubiquitination; and proteolysis involved in protein catabolic process. Located in nucleus. Orthologous to human UBE4B (ubiquitination factor E4B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See UFD2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (118707..121592, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Arf family GTPase ARF1 Neighboring gene ribosomal 60S subunit protein L35A Neighboring gene Rbs1p Neighboring gene phosphoprotein phosphatase 2A catalytic subunit PPH22

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. E4 ubiquitin ligase promotes mitofusin turnover and mitochondrial stress response.
    Title: E4 ubiquitin ligase promotes mitofusin turnover and mitochondrial stress response.
  2. Study results suggest that Ufd2p functions by switching ubiquitin chain linkages to allow the degradation of proteins modified with a ubiquitin linkage, which is normally not targeted to the proteasome.
    Title: Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains.
  3. The action of Cdc48 could free Rad23 from Ufd2 to allow its subsequent association with Rpn1, which in turn may facilitate the orderly transfer of the substrate from the ubiquitylation apparatus to the proteasome.
    Title: The Cdc48 ATPase modulates the interaction between two proteolytic factors Ufd2 and Rad23.
  4. Data present the crystal structures of Ufd2 in complex with the UBL domains of Rad23 and Dsk2.
    Title: The yeast E4 ubiquitin ligase Ufd2 interacts with the ubiquitin-like domains of Rad23 and Dsk2 via a novel and distinct ubiquitin-like binding domain.
  5. can function as a bona fide E3 ubiquitin ligase to promote ubiquitin chain elongation on a substrate
    Title: Structure and function of the yeast U-box-containing ubiquitin ligase Ufd2p.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-ubiquitin ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-ubiquitin ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-ubiquitin ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in ERAD pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to ethanol IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquitin-ubiquitin ligase UFD2
NP_010091.2
  • Conserved ubiquitin (Ub) chain assembly factor (E4); forms branched Ub chains on substrates destined for degradation, catalyzing K48-linked multi-monoubiquitination of K29-linked Ub chains assembled by Ub-ligase Ufd4p; involved in Ub-fusion degradation pathway, OLE membrane fluidity pathway, stress response survival, and ERAD pathway for misfolded proteins where it promotes ubiquitination and transfer of ERAD substrates to Rad23p; U-box family member; homologous to human Ufd2a, Ufd2b

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    118707..121592 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180250.2 → NP_010091.2  TPA: ubiquitin-ubiquitin ligase UFD2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010091.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRG3, P54860
    UniProtKB/TrEMBL
    B3LH73, C7GX41, G2WBX6, N1P586
    Conserved Domains (1) summary
    COG5113
    Location:1 → 961
    UFD2; Ubiquitin fusion degradation protein 2 [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54860.3

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