BUD14 protein phosphatase regulator BUD14 [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: BUD14
Official Full Name: protein phosphatase regulator BUD14
Primary source: SGD:S000000069
Locus tag: YAR014C
See related: AllianceGenome:SGD:S000000069; FungiDB:YAR014C; VEuPathDB:YAR014C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables protein phosphatase regulator activity. Involved in several processes, including regulation of actin filament organization; regulation of cell cycle process; and regulation of cell shape. Located in cellular bud neck; cellular bud tip; and incipient cellular bud site. Part of Kelch-containing formin regulatory complex. [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See BUD14 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 1

Sequence:: Chromosome: I; NC_001133.9 (166742..168871, complement)

Chromosome I - NC_001133.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein phosphatase 1 in association with Bud14 inhibits mitotic exit in Saccharomyces cerevisiae.
Title: Protein phosphatase 1 in association with Bud14 inhibits mitotic exit in Saccharomyces cerevisiae.
Formin-regulating sequences in Smy1 and Bud14 are required for the control of actin cable assembly.
Title: Common formin-regulating sequences in Smy1 and Bud14 are required for the control of actin cable assembly in vivo.
Bud14, Kel1, and Kel2 interact to form a stable 520-kDa complex that controls actin cable assembly and cell morphogenesis.
Title: Saccharomyces cerevisiae Kelch proteins and Bud14 protein form a stable 520-kDa formin regulatory complex that controls actin cable assembly and cell morphogenesis.
formin displacement from growing barbed ends by bud14 is critical for actin cable architecture and function
Title: Displacement of formins from growing barbed ends by bud14 is critical for actin cable architecture and function.
the Ccr4-Not complex independently controls TFIID promoter distribution and Msn2-dependent trans-activation through a process involving a Glc7/Bud14 phosphatase
Title: The Ccr4-Not complex independently controls both Msn2-dependent transcriptional activation--via a newly identified Glc7/Bud14 type I protein phosphatase module--and TFIID promoter distribution.
Bud14p functions as a regulatory subunit of the Glc7p type-I phosphatase to stabilize MT interactions specifically at sites of polarized growth.
Title: The Bud14p-Glc7p complex functions as a cortical regulator of dynein in budding yeast.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables protein phosphatase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein phosphatase regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of actin cytoskeleton polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of actin filament polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of actin filament polymerization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cytokinesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of formin-nucleated actin cable assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Kelch-containing formin regulatory complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell tip	IBA Inferred from Biological aspect of Ancestor more info
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud tip	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in incipient cellular bud site	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: protein phosphatase regulator BUD14

NP_009408.3

Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; forms a complex with Kel1p and Kel2p that regulates Bnr1p (formin) to affect actin cable assembly, cytokinesis, and polarized growth; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001133.9 Reference assembly

Range

166742..168871 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178215.2 → NP_009408.3 TPA: protein phosphatase regulator BUD14 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009408.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VPM3, P27637

UniProtKB/TrEMBL

A7A0H2, C7GUF5, N1P8X7

Conserved Domains (1) summary

pfam00018
Location:266 → 312

SH3_1; SH3 domain