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GPB2 Gpb2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851243, updated on 2-Nov-2024

Summary

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Official Symbol
GPB2
Official Full Name
Gpb2p
Primary source
SGD:S000000052
Locus tag
YAL056W
See related
AllianceGenome:SGD:S000000052; FungiDB:YAL056W; VEuPathDB:YAL056W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
KRH1
Summary
Enables GTPase activating protein binding activity and cAMP-dependent protein kinase inhibitor activity. Involved in several processes, including invasive growth in response to glucose limitation; negative regulation of Ras protein signal transduction; and pseudohyphal growth. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See GPB2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (39259..41901)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene Ecm1p Neighboring gene calnexin Neighboring gene ubiquitin-protein transferase activating protein PEX22 Neighboring gene acetate--CoA ligase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Krh1p and Krh2p act downstream of the Gpa2p G(alpha) subunit to negatively regulate haploid invasive growth. Batlle M, et al. J Cell Sci, 2003 Feb 15. PMID 12538771
  2. Changes in the distribution of fitness effects and adaptive mutational spectra following a single first step towards adaptation. Aggeli D, et al. Nat Commun, 2021 Aug 31. PMID 34465770, Free PMC Article
  3. Kelch repeat protein interacts with the yeast Galpha subunit Gpa2p at a site that couples receptor binding to guanine nucleotide exchange. Niranjan T, et al. J Biol Chem, 2007 Aug 17. PMID 17584745
  4. Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation. Kinsler G, et al. Elife, 2020 Dec 2. PMID 33263280, Free PMC Article
  5. KRH1 and KRH2 are functionally non-redundant in signaling for pseudohyphal differentiation in Saccharomyces cerevisiae. Iyer RS, et al. Curr Genet, 2017 Oct. PMID 28247024

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gpb1 and Gpb2 oppose PKA activity by blocking the ability of PKA to inhibit Bcy1 phosphorylation
    Title: Nutrient control of yeast PKA activity involves opposing effects on phosphorylation of the Bcy1 regulatory subunit.
  2. Gpa2 relieves the inhibition imposed by the kelch-repeat proteins on Protein Kinase A (PKA), thereby bypassing adenylate cyclase for direct regulation of PKA.
    Title: Kelch-repeat proteins interacting with the Galpha protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast.
  3. Gpb1/2 bind to a conserved C-terminal domain of Ira1/2, and loss of Gpb1/2 results in a destabilization of Ira1 and Ira2, leading to elevated levels of Ras2-GTP and unbridled cAMP-PKA signaling.
    Title: The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTPase activating protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables cAMP-dependent protein kinase inhibitor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ascospore formation HMP PubMed 
involved_in glucose mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in glucose mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in invasive growth in response to glucose limitation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in invasive growth in response to glucose limitation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of Ras protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in pseudohyphal growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in pseudohyphal growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Gpb2p
NP_009345.3
  • Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; GPB2 has a paralog, GPB1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    39259..41901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178199.2 → NP_009345.3  TPA: Gpb2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009345.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPG2, P39716, P39717
    UniProtKB/TrEMBL
    G2W8H6
    Conserved Domains (1) summary
    pfam13854
    Location:278 → 316
    Kelch_5; Kelch motif
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39717.4

Gene LinkOut

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