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BDH2 putative dehydrogenase BDH2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851238, updated on 18-Sep-2024

Summary

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Official Symbol
BDH2
Official Full Name
putative dehydrogenase BDH2
Primary source
SGD:S000000057
Locus tag
YAL061W
See related
AllianceGenome:SGD:S000000057; FungiDB:YAL061W; VEuPathDB:YAL061W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable (R,R)-butanediol dehydrogenase activity. Predicted to be involved in butanediol biosynthetic process. Located in cytoplasm and nucleus. Orthologous to human ZADH2 (zinc binding alcohol dehydrogenase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See BDH2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (33448..34701)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene flocculin FLO9 Neighboring gene glutamate dehydrogenase (NADP(+)) GDH3 Neighboring gene (R,R)-butanediol dehydrogenase Neighboring gene Ecm1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. New insights into two yeast BDHs from the PDH subfamily as aldehyde reductases in context of detoxification of lignocellulosic aldehyde inhibitors. Kuang X, et al. Appl Microbiol Biotechnol, 2020 Aug. PMID 32556414
  2. The yeast ADH7 promoter enables gene expression under pronounced translation repression caused by the combined stress of vanillin, furfural, and 5-hydroxymethylfurfural. Ishida Y, et al. J Biotechnol, 2017 Jun 20. PMID 28458045
  3. Prioritized Expression of BDH2 under Bulk Translational Repression and Its Contribution to Tolerance to Severe Vanillin Stress in Saccharomyces cerevisiae. Ishida Y, et al. Front Microbiol, 2016. PMID 27458450, Free PMC Article
  4. Increasing Yield of 2,3,5,6-Tetramethylpyrazine in Baijiu Through Saccharomyces cerevisiae Metabolic Engineering. Cui DY, et al. Front Microbiol, 2020. PMID 33324376, Free PMC Article
  5. The VFH1 (YLL056C) promoter is vanillin-inducible and enables mRNA translation despite pronounced translation repression caused by severe vanillin stress in Saccharomyces cerevisiae. Nguyen TTM, et al. Yeast, 2018 Jul. PMID 29575020

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables (R,R)-butanediol dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables diacetyl reductase ((R)-acetoin forming) (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in butanediol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative dehydrogenase BDH2
NP_009340.1
  • Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    33448..34701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178203.1 → NP_009340.1  TPA: putative dehydrogenase BDH2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009340.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPF8, P39713
    UniProtKB/TrEMBL
    A0A7S8WHP8, A7A0A8, C8Z3M8, G2W8H2
    Conserved Domains (1) summary
    cd08233
    Location:1 → 375
    butanediol_DH_like; (2R,3R)-2,3-butanediol dehydrogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39713.1

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