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MAK16 ribosome biosynthesis protein MAK16 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851208, updated on 2-Nov-2024

Summary

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Official Symbol
MAK16
Official Full Name
ribosome biosynthesis protein MAK16
Primary source
SGD:S000000023
Locus tag
YAL025C
See related
AllianceGenome:SGD:S000000023; FungiDB:YAL025C; VEuPathDB:YAL025C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of preribosome, large subunit precursor. Orthologous to human MAK16 (MAK16 homolog). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MAK16 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (100225..101145, complement)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene DNA-binding protein SAW1 Neighboring gene aminophospholipid-translocating P4-type ATPase DRS2 Neighboring gene ncRNA Neighboring gene mitotic regulator LTE1 Neighboring gene dolichyl-phosphate-mannose-protein mannosyltransferase PMT2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mak16p is required for the maturation of 25S and 5.8S rRNAs in the yeast Saccharomyces cerevisiae. Pellett S, et al. Yeast, 2006 May. PMID 16710831
  2. Host function of MAK16: G1 arrest by a mak16 mutant of Saccharomyces cerevisiae. Wickner RB. Proc Natl Acad Sci U S A, 1988 Aug. PMID 3045810, Free PMC Article
  3. Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: isolation of the MAK16 gene and analysis of an adjacent gene essential for growth at low temperatures. Wickner RB, et al. Yeast, 1987 Mar. PMID 3332963
  4. SmMAK16, the Schistosoma mansoni homologue of MAK16 from yeast, targets protein transport to the nucleolus. Milhon JL, et al. Mol Biochem Parasitol, 2000 May. PMID 10838225
  5. Molecular characterization of chromosomal genes affecting double-stranded RNA replication in Saccharomyces cerevisiae. Icho T, et al. Basic Life Sci, 1986. PMID 3551912

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mak16p is required for the maturation of 25S and 5.8S rRNAs in Saccharomyces cerevisiae.
    Title: Mak16p is required for the maturation of 25S and 5.8S rRNAs in the yeast Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in maturation of 5.8S rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maturation of LSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of preribosome, large subunit precursor IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ribosome biosynthesis protein MAK16
NP_009377.2
  • Essential nuclear protein; constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    100225..101145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178170.2 → NP_009377.2  TPA: ribosome biosynthesis protein MAK16 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009377.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPJ3, P10962
    UniProtKB/TrEMBL
    A7A0E3, B3LUV9, B5VDJ6, C7GPL0, C8Z3K2, G2W8K7, N1P8W4
    Conserved Domains (1) summary
    COG5129
    Location:1 → 306
    MAK16; Nuclear protein with HMG-like acidic region [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10962.2

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