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MTW1 MIND complex subunit MTW1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851197, updated on 2-Nov-2024

Summary

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Official Symbol
MTW1
Official Full Name
MIND complex subunit MTW1
Primary source
SGD:S000000032
Locus tag
YAL034W-A
See related
AllianceGenome:SGD:S000000032; FungiDB:YAL034W-A; VEuPathDB:YAL034W-A
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DSN3; NSL2
Summary
Involved in chromosome segregation and protein localization to kinetochore. Located in spindle pole. Part of MIS12/MIND type complex. Orthologous to human MIS12 (MIS12 kinetochore complex component). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MTW1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (79718..80587)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene GTP-binding protein RBG1 Neighboring gene translation initiation factor eIF5B Neighboring gene Fun19p Neighboring gene RNA-binding protein POP5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Establishing biorientation occurs with precocious separation of the sister kinetochores, but not the arms, in the early spindle of budding yeast. Goshima G, et al. Cell, 2000 Mar 17. PMID 10761928
  2. Temporal characterization of homology-independent centromere coupling in meiotic prophase. Obeso D, et al. PLoS One, 2010 Apr 23. PMID 20428251, Free PMC Article
  3. Control of the spindle checkpoint by lateral kinetochore attachment and limited Mad1 recruitment. Krefman NI, et al. Mol Biol Cell, 2015 Jul 15. PMID 26023090, Free PMC Article
  4. DNA topoisomerase II is a determinant of the tensile properties of yeast centromeric chromatin and the tension checkpoint. Warsi TH, et al. Mol Biol Cell, 2008 Oct. PMID 18701701, Free PMC Article
  5. Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins. Meraldi P, et al. Genome Biol, 2006. PMID 16563186, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in kinetochore assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of MIS12/MIND type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MIS12/MIND type complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MIND complex subunit MTW1
NP_009367.1
  • Essential component of the MIND kinetochore complex; joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly; complex consists of Mtw1p Including Nnf1p-Nsl1p-Dsn1p (MIND)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    79718..80587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178179.1 → NP_009367.1  TPA: MIND complex subunit MTW1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009367.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPI3, P39731
    UniProtKB/TrEMBL
    A7A0D3, B3LUW9, C7GPK0, C8Z3F8, G2W8J7, N1P9S8
    Conserved Domains (1) summary
    pfam05859
    Location:11 → 145
    Mis12; Mis12 protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39731.2

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