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YRF1-5 Y' element ATP-dependent helicase protein 1 copy 5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851189, updated on 2-Nov-2024

Summary

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Official Symbol
YRF1-5
Official Full Name
Y' element ATP-dependent helicase protein 1 copy 5
Primary source
SGD:S000004459
Locus tag
YLR467W
See related
AllianceGenome:SGD:S000004459; FungiDB:YLR467W; VEuPathDB:YLR467W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YRF1
Summary
Predicted to enable DNA helicase activity. Involved in telomere maintenance via recombination. Predicted to be located in nucleus. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See YRF1-5 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (1072508..1077898)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Y' element ATP-dependent helicase protein 1 copy 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-wide array-CGH analysis reveals YRF1 gene copy number variation that modulates genetic stability in distillery yeasts. Deregowska A, et al. Oncotarget, 2015 Oct 13. PMID 26384347, Free PMC Article
  2. A genetic screen for yeast genes induced by sustained osmotic stress. Runner VM, et al. Yeast, 2003 Jul 30. PMID 12868060
  3. Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is induced in survivors defective for telomerase. Yamada M, et al. J Biol Chem, 1998 Dec 11. PMID 9837911
  4. The heme a synthase Cox15 associates with cytochrome c oxidase assembly intermediates during Cox1 maturation. Bareth B, et al. Mol Cell Biol, 2013 Oct. PMID 23979592, Free PMC Article
  5. Growth-Regulated Hsp70 Phosphorylation Regulates Stress Responses and Prion Maintenance. Kao CH, et al. Mol Cell Biol, 2020 May 28. PMID 32205407, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
involved_in telomere maintenance via recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in telomere maintenance via recombination IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
Y' element ATP-dependent helicase protein 1 copy 5
NP_013572.3
  • Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    1072508..1077898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182355.3 → NP_013572.3  TPA: Y' element ATP-dependent helicase protein 1 copy 5 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013572.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTG2, O94087, P0CX20, P0CX21, P0CX22, P24088, P24089, Q53WX0, Q99313
    Conserved Domains (2) summary
    COG0513
    Location:736 → 1225
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam11603
    Location:13 → 88
    Sir1; Regulatory protein Sir1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CX20.1
P0CX21.1
P0CX22.1

Gene LinkOut

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