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LSM3 U4/U6-U5 snRNP complex subunit LSM3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851159, updated on 3-Nov-2024

Summary

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Official Symbol
LSM3
Official Full Name
U4/U6-U5 snRNP complex subunit LSM3
Primary source
SGD:S000006434
Locus tag
YLR438C-A
See related
AllianceGenome:SGD:S000006434; FungiDB:YLR438C-A; VEuPathDB:YLR438C-A
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SMX4; USS2
Summary
Contributes to RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleolus. Part of Lsm1-7-Pat1 complex; sno(s)RNA-containing ribonucleoprotein complex; and spliceosomal snRNP complex. Orthologous to human LSM3 (LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See LSM3 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (1013909..1014178, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Dif1p Neighboring gene ornithine-oxo-acid transaminase Neighboring gene mitochondrial 54S ribosomal protein YmL4 Neighboring gene Sec39p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A complex pathway for 3' processing of the yeast U3 snoRNA. Kufel J, et al. Nucleic Acids Res, 2003 Dec 1. PMID 14627812, Free PMC Article
  2. Homomeric ring assemblies of eukaryotic Sm proteins have affinity for both RNA and DNA. Crystal structure of an oligomeric complex of yeast SmF. Collins BM, et al. J Biol Chem, 2003 May 9. PMID 12618433
  3. A conditional U5 snRNA mutation affecting pre-mRNA splicing and nuclear pre-mRNA retention identifies SSD1/SRK1 as a general splicing mutant suppressor. Luukkonen BG, et al. Nucleic Acids Res, 1999 Sep 1. PMID 10446233, Free PMC Article
  4. Crystal structure of Lsm3 octamer from Saccharomyces cerevisiae: implications for Lsm ring organisation and recruitment. Naidoo N, et al. J Mol Biol, 2008 Apr 11. PMID 18329667
  5. Characterization of U6 snRNA-protein interactions. Vidal VP, et al. RNA, 1999 Nov. PMID 10580475, Free PMC Article

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Growth-regulated co-occupancy of Mediator and Lsm3 at intronic ribosomal protein genes.
    Title: Growth-regulated co-occupancy of Mediator and Lsm3 at intronic ribosomal protein genes.
  2. The N-terminal helix of Lsm3 intreacting with the structure of the C-terminal domain of Pat1 suggests a potential mechanism for RNA binding that involves the helix and loop faces of the Lsm1-7 ring.
    Title: Lsm2 and Lsm3 bridge the interaction of the Lsm1-7 complex with Pat1 for decapping activation.
  3. The Lsm3 structure thus provides evidence for protein-protein interactions likely utilised by the highly variable Lsm loops and termini in the recruitment of RNA processing factors to mixed Lsm ring scaffolds.
    Title: Crystal structure of Lsm3 octamer from Saccharomyces cerevisiae: implications for Lsm ring organisation and recruitment.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in P-body assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Lsm1-7-Pat1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Lsm1-7-Pat1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U4/U6 x U5 tri-snRNP complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U6 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U6 snRNP IDA
Inferred from Direct Assay
more info
 PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of sno(s)RNA-containing ribonucleoprotein complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
U4/U6-U5 snRNP complex subunit LSM3
NP_013543.3
  • Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    1013909..1014178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184308.3 → NP_013543.3  TPA: U4/U6-U5 snRNP complex subunit LSM3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013543.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ73, P57743, Q05176, Q06759
    UniProtKB/TrEMBL
    A7A1V8, B3RHU7, C7GSL7, C8ZE46, G2WJP9, N1NYV8
    Conserved Domains (1) summary
    cd01730
    Location:4 → 78
    LSm3; Like-Sm protein 3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P57743.1

Gene LinkOut

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