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ATG23 Atg23p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851151, updated on 2-Nov-2024

Summary

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Official Symbol
ATG23
Official Full Name
Atg23p
Primary source
SGD:S000004423
Locus tag
YLR431C
See related
AllianceGenome:SGD:S000004423; FungiDB:YLR431C; VEuPathDB:YLR431C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CVT23
Summary
Involved in cytoplasm to vacuole targeting by the Cvt pathway; macroautophagy; and positive regulation of macroautophagy. Located in phagophore assembly site. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ATG23 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (1000342..1001703, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Crn1p Neighboring gene DNA/RNA helicase SEN1 Neighboring gene IMP dehydrogenase IMD3 Neighboring gene calcineurin catalytic subunit A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Atg23 is essential for the cytoplasm to vacuole targeting pathway and efficient autophagy but not pexophagy. Tucker KA, et al. J Biol Chem, 2003 Nov 28. PMID 14504273, Free PMC Article
  2. ATG23, a novel gene required for maturation of proaminopeptidase I, but not for autophagy. Meiling-Wesse K, et al. FEMS Yeast Res, 2004 Jan. PMID 14734026
  3. Dimerization-dependent membrane tethering by Atg23 is essential for yeast autophagy. Hawkins WD, et al. Cell Rep, 2022 Apr 19. PMID 35443167, Free PMC Article
  4. A cycling protein complex required for selective autophagy. Legakis JE, et al. Autophagy, 2007 Sep-Oct. PMID 17426440
  5. Phosphorylation of Atg9 regulates movement to the phagophore assembly site and the rate of autophagosome formation. Feng Y, et al. Autophagy, 2016. PMID 27050455, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TOR-mediated Ypt1 phosphorylation regulates autophagy initiation complex assembly.
    Title: TOR-mediated Ypt1 phosphorylation regulates autophagy initiation complex assembly.
  2. Overexpression of Atg23 inhibits Atg9 trafficking to the phagophore assembly site.
    Title: Atg23 and Atg27 act at the early stages of Atg9 trafficking in S. cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to phagophore assembly site IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in phagophore assembly site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagophore assembly site membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Atg23p
NP_013535.1
  • Peripheral membrane protein required for autophagy and CVT; required for cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    1000342..1001703 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182319.1 → NP_013535.1  TPA: Atg23p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013535.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ66, Q06671
    UniProtKB/TrEMBL
    B3RHU0, B5VNW9, N1P089
    Conserved Domains (1) summary
    pfam12128
    Location:149 → 329
    DUF3584; Protein of unknown function (DUF3584)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06671.1

Gene LinkOut

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