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AFG2 AAA family ATPase AFG2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851113, updated on 14-Nov-2024

Summary

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Official Symbol
AFG2
Official Full Name
AAA family ATPase AFG2
Primary source
SGD:S000004389
Locus tag
YLR397C
See related
AllianceGenome:SGD:S000004389; FungiDB:YLR397C; VEuPathDB:YLR397C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DRG1
Summary
Enables ATP hydrolysis activity. Involved in response to xenobiotic stimulus and ribosomal large subunit biogenesis. Part of preribosome, large subunit precursor. Orthologous to human AFG2A (AFG2 AAA ATPase homolog A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See AFG2 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (912550..914892, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit VIII Neighboring gene tethering complex ATP-binding subunit VPS33 Neighboring gene SKI complex RNA helicase subunit SKI2 Neighboring gene chromatin-binding protein BDF1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. AFG2, an essential gene in yeast, encodes a new member of the Sec18p, Pas1p, Cdc48p, TBP-1 family of putative ATPases. Thorsness PE, et al. Yeast, 1993 Nov. PMID 8109176
  2. Structural and enzymatic properties of the AAA protein Drg1p from Saccharomyces cerevisiae. Decoupling of intracellular function from ATPase activity and hexamerization. Zakalskiy A, et al. J Biol Chem, 2002 Jul 26. PMID 12006565
  3. Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine. Prattes M, et al. Nat Commun, 2021 Jun 9. PMID 34108481, Free PMC Article
  4. Diazaborine resistance in the yeast Saccharomyces cerevisiae reveals a link between YAP1 and the pleiotropic drug resistance genes PDR1 and PDR3. Wendler F, et al. J Biol Chem, 1997 Oct 24. PMID 9341149
  5. Diazaborine treatment of Baker's yeast results in stabilization of aberrant mRNAs. Jungwirth H, et al. J Biol Chem, 2001 Sep 28. PMID 11477081

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1.
    Title: Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1.
  2. Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine.
    Title: Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine.
  3. the AAA-ATPase Drg1 as a target of diazaborine. Inhibitor binding into the second AAA domain of Drg1 requires ATP loading and results in inhibition of ATP hydrolysis in this site.
    Title: The drug diazaborine blocks ribosome biogenesis by inhibiting the AAA-ATPase Drg1.
  4. Data suggest that the ATPase activity of Drg1 is required for the release of shuttling proteins from the pre-60S particles shortly after their nuclear export.
    Title: Cytoplasmic recycling of 60S preribosomal factors depends on the AAA protein Drg1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H2AZ histone chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H3-H4 histone complex chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA clamp loader activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin extrusion motor activity IEA
Inferred from Electronic Annotation
more info
  
enables cohesin loader activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin looping IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, large subunit precursor IDA
Inferred from Direct Assay
more info
 PubMed 
part_of preribosome, large subunit precursor IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
AAA family ATPase AFG2
NP_013501.1
  • ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; releases Rlp24p from purified pre-60S particles in vitro; target of the ribosomal biosynthesis inhibitor diazaborine; may be involved in degradation of aberrant mRNAs

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    912550..914892 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182285.1 → NP_013501.1  TPA: AAA family ATPase AFG2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013501.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ32, P32794
    UniProtKB/TrEMBL
    A7A1S2, C8ZE06, G2WJL2, N1NZT6
    Conserved Domains (1) summary
    TIGR01243
    Location:51 → 773
    CDC48; AAA family ATPase, CDC48 subfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32794.1

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