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TAD3 Tad3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851027, updated on 2-Nov-2024

Summary

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Official Symbol
TAD3
Official Full Name
Tad3p
Primary source
SGD:S000004308
Locus tag
YLR316C
See related
AllianceGenome:SGD:S000004308; FungiDB:YLR316C; VEuPathDB:YLR316C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables tRNA-specific adenosine deaminase activity. Involved in tRNA modification. Located in peroxisome. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with brain abnormalities, poor growth, and dysmorphic facies. Orthologous to human ADAT3 (adenosine deaminase tRNA specific 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See TAD3 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
3
Sequence:
Chromosome: XII; NC_001144.5 (765266..766358, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Sph1p Neighboring gene septin CDC3 Neighboring gene Nkp2p Neighboring gene telomerase reverse transcriptase Neighboring gene Bud6p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mechanism, specificity and general properties of the yeast enzyme catalysing the formation of inosine 34 in the anticodon of transfer RNA. Auxilien S, et al. J Mol Biol, 1996 Oct 4. PMID 8893855
  2. The CGA codon decoding through tRNA(Arg) (ICG) supply governed by Tad2/Tad3 in Saccharomyces cerevisiae. Wada M, et al. FEBS J, 2023 Jul. PMID 36806932
  3. Crystal structure of the yeast heterodimeric ADAT2/3 deaminase. Liu X, et al. BMC Biol, 2020 Dec 3. PMID 33272269, Free PMC Article
  4. An adenosine deaminase that generates inosine at the wobble position of tRNAs. Gerber AP, et al. Science, 1999 Nov 5. PMID 10550050
  5. Mutator effects and mutation signatures of editing deaminases produced in bacteria and yeast. Lada AG, et al. Biochemistry (Mosc), 2011 Jan. PMID 21568845, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The CGA codon decoding through tRNA[Arg] (ICG) supply governed by Tad2/Tad3 in Saccharomyces cerevisiae.
    Title: The CGA codon decoding through tRNA(Arg) (ICG) supply governed by Tad2/Tad3 in Saccharomyces cerevisiae.
  2. Crystal structure of the ADAT2-ADAT3 heterodimer. [ADAT2, ADAT3]
    Title: Biochemical and structural studies of A-to-I editing by tRNA:A34 deaminases at the wobble position of transfer RNA.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-specific adenosine deaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to tRNA-specific adenosine-34 deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in nucleobase-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA modification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Tad3p
NP_013420.2
  • Subunit of tRNA-specific adenosine-34 deaminase; forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs; localizes to cytosol, nucleus and peroxisomes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    765266..766358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182205.1 → NP_013420.2  TPA: Tad3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013420.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYW0, O13552, Q9URQ3
    UniProtKB/TrEMBL
    G2WJD9
    Conserved Domains (1) summary
    COG0590
    Location:149 → 318
    TadA; tRNA(Arg) A34 adenosine deaminase TadA [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9URQ3.1

Gene LinkOut

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