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GSP1 Ran GTPase GSP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851000, updated on 2-Nov-2024

Summary

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Official Symbol
GSP1
Official Full Name
Ran GTPase GSP1
Primary source
SGD:S000004284
Locus tag
YLR293C
See related
AllianceGenome:SGD:S000004284; FungiDB:YLR293C; VEuPathDB:YLR293C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CNR1; CST17
Summary
Enables GTPase activity. Involved in several processes, including exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nucleocytoplasmic transport; and regulation of nucleocytoplasmic transport. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human RAN (RAN, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See GSP1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (720771..721430, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene translation initiation factor eIF2B subunit beta Neighboring gene Sec63 complex subunit SEC72 Neighboring gene F1F0 ATP synthase subunit h Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nuclear protein import, but not mRNA export, is defective in all Saccharomyces cerevisiae mutants that produce temperature-sensitive forms of the Ran GTPase homologue Gsp1p. Oki M, et al. Mol Gen Genet, 1998 Apr. PMID 9604885
  2. Three tRNA nuclear exporters in S. cerevisiae: parallel pathways, preferences, and precision. Chatterjee K, et al. Nucleic Acids Res, 2022 Sep 23. PMID 36099418, Free PMC Article
  3. High levels of the GTPase Ran/TC4 relieve the requirement for nuclear protein transport factor 2. Paschal BM, et al. J Biol Chem, 1997 Aug 22. PMID 9261173
  4. The small GTPase Gsp1p binds to the repeat domain of the nucleoporin Nsp1p. Stochaj U, et al. Biochem J, 1998 Feb 15. PMID 9461539, Free PMC Article
  5. A 2.1-Å-resolution crystal structure of unliganded CRM1 reveals the mechanism of autoinhibition. Saito N, et al. J Mol Biol, 2013 Jan 23. PMID 23164569

See all (156) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Systems-level effects of allosteric perturbations to a model molecular switch.
    Title: Systems-level effects of allosteric perturbations to a model molecular switch.
  2. Altered metabolic regulation owing to gsp1 mutations encoding the nuclear small G protein in Saccharomyces cerevisiae.
    Title: Altered metabolic regulation owing to gsp1 mutations encoding the nuclear small G protein in Saccharomyces cerevisiae.
  3. Cex1p recruits Rna1p from the cytoplasm to the nuclear pore complex and facilitates Rna1p activation of the GTPase activity of Gsp1p by enabling Rna1p to gain access to Gsp1p-GTP bound to the Los1p-tRNA-Gsp1p-GTP export complex.
    Title: Cex1p facilitates Rna1p-mediated dissociation of the Los1p-tRNA-Gsp1p-GTP export complex.
  4. Study proved that the additional beta-wedge in Prp20p is essential for the interaction between Prp20p and Gsp1p.
    Title: The 1.9Å crystal structure of Prp20p from Saccharomyces cerevisiae and its binding properties to Gsp1p and histones.
  5. Thus, the Gtr1p-Gtr2p cycle was suggested to regulate the Ran cycle through Yrb2p.
    Title: Saccharomyces cerevisiae GTPase complex: Gtr1p-Gtr2p regulates cell-proliferation through Saccharomyces cerevisiae Ran-binding protein, Yrb2p.
  6. Results suggest that the GSP1 pathway could regulate proper telomeric function in yeast through Sir4p.
    Title: The nuclear GTPase Gsp1p can affect proper telomeric function through the Sir4 protein in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleocytoplasmic transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleus organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in poly(A)+ mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle phase transition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of nucleocytoplasmic transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ribosomal subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ran GTPase GSP1
NP_013396.1
  • Ran GTPase; GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; regulated by Srm1p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p; GSP1 has a paralog, GSP2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    720771..721430 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182181.1 → NP_013396.1  TPA: Ran GTPase GSP1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013396.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYT9, P32835
    UniProtKB/TrEMBL
    A7A1H6, B3RHH3, B5VNJ9, C7GVU4, C8ZDQ7, G2WJB7, N1NZK2
    Conserved Domains (1) summary
    PTZ00132
    Location:4 → 216
    PTZ00132; GTP-binding nuclear protein Ran; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32835.1

Gene LinkOut

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