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YEF3 translation elongation factor EF-3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850951, updated on 3-Nov-2024

Summary

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Official Symbol
YEF3
Official Full Name
translation elongation factor EF-3
Primary source
SGD:S000004239
Locus tag
YLR249W
See related
AllianceGenome:SGD:S000004239; FungiDB:YLR249W; VEuPathDB:YLR249W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
TEF3
Summary
Enables ATP hydrolysis activity; ribosome binding activity; and translation elongation factor activity. Involved in translational elongation and translational termination. Located in cytoplasmic stress granule and cytosolic ribosome. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See YEF3 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (636780..639914)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase IRC20 Neighboring gene serine/threonine protein kinase RCK2 Neighboring gene Ssp120p Neighboring gene ethanol metabolism protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ribosome profiling analysis of eEF3-depleted Saccharomyces cerevisiae. Kasari V, et al. Sci Rep, 2019 Feb 28. PMID 30816176, Free PMC Article
  2. A controllable gene-expression system for the pathogenic fungus Candida glabrata. Nakayama H, et al. Microbiology (Reading), 1998 Sep. PMID 9782488
  3. Yeast translation elongation factor eEF3 promotes late stages of tRNA translocation. Ranjan N, et al. EMBO J, 2021 Mar 15. PMID 33555093, Free PMC Article
  4. Mutations in the chromodomain-like insertion of translation elongation factor 3 compromise protein synthesis through reduced ATPase activity. Sasikumar AN, et al. J Biol Chem, 2014 Feb 21. PMID 24379402, Free PMC Article
  5. Domain and nucleotide dependence of the interaction between Saccharomyces cerevisiae translation elongation factors 3 and 1A. Anand M, et al. J Biol Chem, 2006 Oct 27. PMID 16954224

See all (166) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Frameshifting at collided ribosomes is modulated by elongation factor eEF3 and by integrated stress response regulators Gcn1 and Gcn20.
    Title: Frameshifting at collided ribosomes is modulated by elongation factor eEF3 and by integrated stress response regulators Gcn1 and Gcn20.
  2. Protein aggregation and the evolution of stress resistance in clinical yeast.
    Title: Protein aggregation and the evolution of stress resistance in clinical yeast.
  3. Yeast translation elongation factor eEF3 promotes late stages of tRNA translocation.
    Title: Yeast translation elongation factor eEF3 promotes late stages of tRNA translocation.
  4. Eukaryotic Elongation Factor 3 Protects Saccharomyces cerevisiae Yeast from Oxidative Stress.
    Title: Eukaryotic Elongation Factor 3 Protects Saccharomyces cerevisiae Yeast from Oxidative Stress.
  5. the elongation factor Yef3 was found to interact with mRNA in non-coding regions and in a translation independent manner. These results suggest an additional, non-elongation function for this factor.
    Title: The elongation factor eEF3 (Yef3) interacts with mRNA in a translation independent manner.
  6. Data indicate that the growth defect associated with constitutively active Gcn2 was diminished by eEF3 (YEF3) overexpression.
    Title: Overexpression of eukaryotic translation elongation factor 3 impairs Gcn2 protein activation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation elongation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in translational elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translational termination IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule HDA PubMed 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ribosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
translation elongation factor EF-3
NP_013350.1
  • Translation elongation factor 3; contains two ABC cassettes; binds and hydrolyzes ATP; interacts with mRNA independently of translation; involved in frameshifting at stalled ribosomes; YEF3 has a paralog, HEF3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    636780..639914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182136.1 → NP_013350.1  TPA: translation elongation factor EF-3 [Saccharomyces cerevisiae S288C]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYP7, O93815, P16521, Q06558
    UniProtKB/TrEMBL
    A7A1D2, B3RHD4, B5VNG5, C7GQY7, C8ZDL2, G2WJ75, N1NYG5
    Conserved Domains (3) summary
    COG0488
    Location:431 → 986
    Uup; ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]
    sd00044
    Location:129 → 158
    HEAT; HEAT repeat [structural motif]
    pfam17947
    Location:336 → 411
    4HB; Four helical bundle domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16521.4

Gene LinkOut

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