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CSC1 Csc1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850942, updated on 2-Nov-2024

Summary

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Official Symbol
CSC1
Official Full Name
Csc1p
Primary source
SGD:S000004231
Locus tag
YLR241W
See related
AllianceGenome:SGD:S000004231; FungiDB:YLR241W; VEuPathDB:YLR241W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables calcium-activated cation channel activity. Involved in monoatomic cation transport. Located in endoplasmic reticulum and fungal-type vacuole membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 87 and hypomyelinating leukodystrophy 19. Orthologous to several human genes including TMEM63A (transmembrane protein 63A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CSC1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (620473..622821)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene lipoyl(octanoyl) transferase LIP2 Neighboring gene phosphatidylinositol 3-kinase VPS34 Neighboring gene sterol homeostasis protein ARV1 Neighboring gene putative signal sequence-binding GTPase GPN3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Finding motifs in protein secondary structure for use in function prediction. Ferré S, et al. J Comput Biol, 2006 Apr. PMID 16706721
  2. DUF221 proteins are a family of osmosensitive calcium-permeable cation channels conserved across eukaryotes. Hou C, et al. Cell Res, 2014 May. PMID 24503647, Free PMC Article
  3. A genome-wide synthetic dosage lethality screen reveals multiple pathways that require the functioning of ubiquitin-binding proteins Rad23 and Dsk2. Liu C, et al. BMC Biol, 2009 Nov 12. PMID 19909498, Free PMC Article
  4. The yeast vacuolar membrane proteome. Wiederhold E, et al. Mol Cell Proteomics, 2009 Feb. PMID 19001347
  5. The peroxisomal exportomer directly inhibits phosphoactivation of the pexophagy receptor Atg36 to suppress pexophagy in yeast. Yu H, et al. Elife, 2022 Apr 11. PMID 35404228, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables calcium-activated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-activated cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium-activated cation channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic cation transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Csc1p
NP_013342.1
  • Calcium permeable gated cation channel; functions as an osmosensitive, calcium-permeable cation channel when expressed in a heterologous system; may be involved in detoxification; similar to Arabidopsis CSC1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    620473..622821
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182128.1 → NP_013342.1  TPA: Csc1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013342.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYN9, Q06538
    UniProtKB/TrEMBL
    A7A1C4, B3RHC6, B5VNF8, C7GQZ5, C8ZDK4, G2WJ67, N1NZV5
    Conserved Domains (1) summary
    COG5594
    Location:1 → 782
    COG5594; Uncharacterized integral membrane protein [Function unknown]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06538.1

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