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MSS51 Mss51p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850900, updated on 2-Nov-2024

Summary

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Official Symbol
MSS51
Official Full Name
Mss51p
Primary source
SGD:S000004193
Locus tag
YLR203C
See related
AllianceGenome:SGD:S000004193; FungiDB:YLR203C; VEuPathDB:YLR203C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables translation regulator activity. Involved in mitochondrial cytochrome c oxidase assembly and positive regulation of mitochondrial translation. Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MSS51 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (550650..551960, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene tubulin-binding prefolding complex subunit YKE2 Neighboring gene ubiquinone biosynthesis protein COQ9 Neighboring gene mitochondrial 37S ribosomal protein QRI5 Neighboring gene Hmx1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The physical interaction OF Mss51 & Cox14 depends on Cox1 synthesis, showing dynamic assembly of early cytochrome c oxidase intermediates nucleated by Cox1.
    Title: Dual functions of Mss51 couple synthesis of Cox1 to assembly of cytochrome c oxidase in Saccharomyces cerevisiae mitochondria.
  2. Ssc1, by interacting with Mss51 and Mss51-containing complexes, plays a critical role in Cox1 biogenesis, COX assembly, and the translational regulation of these processes.
    Title: Mss51 and Ssc1 facilitate translational regulation of cytochrome c oxidase biogenesis.
  3. These results support a key role for Mss51p in translationally regulating Cox1p synthesis by the status of cytochrome oxidase assembly.
    Title: Aberrant translation of cytochrome c oxidase subunit 1 mRNA species in the absence of Mss51p in the yeast Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables translation regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial cytochrome c oxidase assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial cytochrome c oxidase assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitochondrial translation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitochondrial translation IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mss51p
NP_013304.1
  • Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; localizes to vacuole membrane in response to H2O2; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    550650..551960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182090.1 → NP_013304.1  TPA: Mss51p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013304.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYK4, P32335
    UniProtKB/TrEMBL
    A7A191, B3RH92, B5VNC0, C7GIT3, G2WJ33, N1NZT5
    Conserved Domains (1) summary
    pfam13824
    Location:85 → 135
    zf-Mss51; Zinc-finger of mitochondrial splicing suppressor 51
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32335.2

Gene LinkOut

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