U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NMT1 glycylpeptide N-tetradecanoyltransferase NMT1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850892, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
NMT1
Official Full Name
glycylpeptide N-tetradecanoyltransferase NMT1
Primary source
SGD:S000004185
Locus tag
YLR195C
See related
AllianceGenome:SGD:S000004185; FungiDB:YLR195C; VEuPathDB:YLR195C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CDC72
Summary
Enables glycylpeptide N-tetradecanoyltransferase activity. Predicted to be involved in protein localization to membrane. Located in cytosol. Orthologous to human NMT1 (N-myristoyltransferase 1) and NMT2 (N-myristoyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See NMT1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (541937..543304, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Ups1p Neighboring gene Ncw2p Neighboring gene rRNA-processing protein PWP1 Neighboring gene snoRNP complex protein NOP56

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The substrate specificity of Saccharomyces cerevisiae myristoyl-CoA: protein N-myristoyltransferase. Polar probes of the enzyme's myristoyl-CoA recognition site. Lu T, et al. J Biol Chem, 1994 Feb 18. PMID 8106519
  2. Optimized expression and purification of myristoylated human neuronal calcium sensor 1 in E. coli. De Cotiis DA, et al. Protein Expr Purif, 2008 Oct. PMID 18634883, Free PMC Article
  3. Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-terminal region. Wu J, et al. J Biol Chem, 2007 Jul 27. PMID 17513302
  4. Unexpected protein families including cell defense components feature in the N-myristoylome of a higher eukaryote. Boisson B, et al. J Biol Chem, 2003 Oct 31. PMID 12912986
  5. Pre-steady-state kinetic studies of Saccharomyces cerevisiae myristoylCoA:protein N-myristoyltransferase mutants identify residues involved in catalysis. Farazi TA, et al. Biochemistry, 2001 Aug 7. PMID 11478885

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Three crystal structures of Saccharomyces cerevisiae NMT: in binary complex with myristoyl-CoA (MYA) alone and in two ternary complexes.
    Title: Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-terminal region.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycylpeptide N-tetradecanoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycylpeptide N-tetradecanoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycylpeptide N-tetradecanoyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-terminal peptidyl-glycine N-myristoylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in N-terminal protein myristoylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
glycylpeptide N-tetradecanoyltransferase NMT1
NP_013296.1
  • N-myristoyl transferase; catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    541937..543304 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182082.1 → NP_013296.1  TPA: glycylpeptide N-tetradecanoyltransferase NMT1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013296.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYJ8, P14743
    UniProtKB/TrEMBL
    B5VNB5, C7GIS7, N1P6S8
    Conserved Domains (1) summary
    COG5092
    Location:1 → 455
    NMT1; N-myristoyl transferase [Lipid metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P14743.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous