UPS1 Ups1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: UPS1
Official Full Name: Ups1p
Primary source: SGD:S000004183
Locus tag: YLR193C
See related: AllianceGenome:SGD:S000004183; FungiDB:YLR193C; VEuPathDB:YLR193C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables phosphatidic acid transfer activity. Involved in cardiolipin metabolic process; phospholipid translocation; and positive regulation of phosphatidylcholine biosynthetic process. Located in mitochondrial inner membrane and mitochondrial intermembrane space. Is extrinsic component of mitochondrial inner membrane. Orthologous to human PRELID1 (PRELI domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See UPS1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (540009..540536, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins has been reported.
Title: Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins.
crystal structure of Ups1-Mdm35 bound with a phosphatidic acid (PA) molecule at 2.0 A resolution; study reveals molecular basis of Ups1-Mdm35-mediated PA binding and transfer and sheds new light on mechanism of intramitochondrial lipid transport by MSF1/PRELI family proteins
Title: Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex.
The Ups1-Mdm35 complex constitutes a single domain that has a deep pocket and flexible Omega-loop lid. A basic residue at the pocket bottom and the Omega-loop lid are important for phosphatidic acid extraction from the membrane following Ups1 binding.
Title: Structural and mechanistic insights into phospholipid transfer by Ups1-Mdm35 in mitochondria.
PS is transferred from the mitochondrial outer membrane to the inner membrane independently of Psd1p, Ups1p, and Ups2p and decarboxylated to PE by Psd1p in the inner membrane
Title: Phosphatidylethanolamine biosynthesis in mitochondria: phosphatidylserine (PS) trafficking is independent of a PS decarboxylase and intermembrane space proteins UPS1P and UPS2P.
study identified Ups1 as a lipid transfer protein that can shuttle phosphatidic acid between mitochondrial membranes; lipid transfer required the dynamic assembly of Ups1 with Mdm35 and allowed conversion of phosphatidic acid to cardiolipin in the inner membrane
Title: Intramitochondrial transport of phosphatidic acid in yeast by a lipid transfer protein.
Data suggest that Ups1p and Up2p proteins may function in phospholipid trafficking between the outer and inner mitochondrial membranes.
Title: Role for two conserved intermembrane space proteins, Ups1p and Ups2p, [corrected] in intra-mitochondrial phospholipid trafficking.
The authors show that Ups1, Ups2 and Ups3 protein import is mediated by another mitochondrial intermembrane space protein, Mdm35p.
Title: Mdm35p imports Ups proteins into the mitochondrial intermembrane space by functional complex formation.
The authors identified Mdm35, a member of the twin Cx9C protein family, as a novel interaction partner of Ups1 and Ups2.
Title: Regulation of mitochondrial phospholipids by Ups1/PRELI-like proteins depends on proteolysis and Mdm35.
Data report that two homologous intermembrane space proteins, Ups1p and Ups2p, control cardiolipin metabolism and affect the assembly state of TIM23 and its association with PAM in an opposing manner.
Title: Ups1p and Ups2p antagonistically regulate cardiolipin metabolism in mitochondria.
deletion strains, ylr193cDelta/ylr193cDelta, yor305wDelta/yor305wDelta, and ypr170cDelta/ypr170cDelta, mate at very low frequencies with haploids of either or both MATa/MATalpha mating types.
Title: Single-gene deletions that restore mating competence to diploid yeast.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phosphatidic acid transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidic acid transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidic acid transfer activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cardiolipin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intermembrane lipid transfer	IEA Inferred from Electronic Annotation more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in phospholipid translocation	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylcholine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial intermembrane space	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ups1p

NP_013294.1

Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI