U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PEX13 peroxin PEX13 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850888, updated on 3-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
PEX13
Official Full Name
peroxin PEX13
Primary source
SGD:S000004181
Locus tag
YLR191W
See related
AllianceGenome:SGD:S000004181; FungiDB:YLR191W; VEuPathDB:YLR191W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PAS20
Summary
Enables protein-macromolecule adaptor activity. Involved in protein import into peroxisome matrix, docking. Located in peroxisomal membrane. Part of peroxisomal importomer complex. Used to study peroxisomal disease. Human ortholog(s) of this gene implicated in Peroxisome biogenesis disorder 11B; peroxisomal disease; and peroxisome biogenesis disorder 11A. Orthologous to human PEX13 (peroxisomal biogenesis factor 13). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PEX13 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (537272..538432)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene sterol 3-beta-glucosyltransferase Neighboring gene Mmr1p Neighboring gene translation initiation factor eIF3 core subunit j Neighboring gene Ups1p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Peroxisome biogenesis disorders: identification of a new complementation group distinct from peroxisome-deficient CHO mutants and not complemented by human PEX 13. Shimozawa N, et al. Biochem Biophys Res Commun, 1998 Feb 13. PMID 9480815
  2. The ScPex13p SH3 domain exposes two distinct binding sites for Pex5p and Pex14p. Pires JR, et al. J Mol Biol, 2003 Mar 7. PMID 12595255
  3. The SH3 domain of the Saccharomyces cerevisiae peroxisomal membrane protein Pex13p functions as a docking site for Pex5p, a mobile receptor for the import PTS1-containing proteins. Elgersma Y, et al. J Cell Biol, 1996 Oct. PMID 8858166, Free PMC Article
  4. An efficient positive selection procedure for the isolation of peroxisomal import and peroxisome assembly mutants of Saccharomyces cerevisiae. Elgersma Y, et al. Genetics, 1993 Nov. PMID 7507454, Free PMC Article
  5. Hansenula polymorpha Pex19p is essential for the formation of functional peroxisomal membranes. Otzen M, et al. J Biol Chem, 2004 Apr 30. PMID 14981078

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data demonstrate that Pex8p is capable to interact with the PTS2-receptor Pex7p and the docking complex component Pex13p with its C-terminal SH3-domain providing the binding site.
    Title: Targeting of Pex8p to the peroxisomal importomer.
  2. A novel Pex-14 binding site in Pex13 was identified, which is essential for peroxisomal protein import.
    Title: Identification of a novel, intraperoxisomal pex14-binding site in pex13: association of pex13 with the docking complex is essential for peroxisomal matrix protein import.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein import into peroxisome matrix, docking IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into peroxisome matrix, docking IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into peroxisome matrix, docking IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein import into peroxisome matrix, docking IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of peroxisomal importomer complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of peroxisomal importomer complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
peroxin PEX13
NP_013292.1
  • Peroxisomal importomer complex component; integral peroxisomal membrane protein required for docking and translocation of peroxisomal matrix proteins; interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p; forms a complex with Pex14p and Pex17p; human homolog PEX13 complements yeast null mutant

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    537272..538432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182078.1 → NP_013292.1  TPA: peroxin PEX13 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013292.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYJ4, P80667
    UniProtKB/TrEMBL
    A7A181, B5VNB0, C7GIX8, N1P6S5
    Conserved Domains (2) summary
    cd11771
    Location:310 → 369
    SH3_Pex13p_fungal; Src Homology 3 domain of fungal peroxisomal membrane protein Pex13p
    pfam04088
    Location:140 → 283
    Peroxin-13_N; Peroxin 13, N-terminal region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P80667.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.