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MMR1 Mmr1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850887, updated on 2-Nov-2024

Summary

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Official Symbol
MMR1
Official Full Name
Mmr1p
Primary source
SGD:S000004180
Locus tag
YLR190W
See related
AllianceGenome:SGD:S000004180; FungiDB:YLR190W; VEuPathDB:YLR190W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phospholipid binding activity. Involved in mitochondrion inheritance. Acts upstream of or within intracellular distribution of mitochondria. Located in several cellular components, including cortical endoplasmic reticulum; incipient cellular bud site; and mitochondrial outer membrane. Is active in cellular bud. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MMR1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (535214..536689)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette permease MDL1 Neighboring gene sterol 3-beta-glucosyltransferase Neighboring gene peroxin PEX13 Neighboring gene translation initiation factor eIF3 core subunit j

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitochondrial quality control during inheritance is associated with lifespan and mother-daughter age asymmetry in budding yeast. McFaline-Figueroa JR, et al. Aging Cell, 2011 Oct. PMID 21726403, Free PMC Article
  2. [Phosphorylation of YLR190w by PAP1 PHO85 kinase complex]. Shi XZ, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 2002 Mar. PMID 12006994
  3. Selective retention of dysfunctional mitochondria during asymmetric cell division in yeast. Chelius X, et al. PLoS Biol, 2023 Sep. PMID 37721958, Free PMC Article
  4. A role for cell polarity in lifespan and mitochondrial quality control in the budding yeast Saccharomyces cerevisiae. Yang EJ, et al. iScience, 2022 Mar 18. PMID 35281729, Free PMC Article
  5. Direct membrane binding and self-interaction contribute to Mmr1 function in mitochondrial inheritance. Chen W, et al. Mol Biol Cell, 2018 Sep 15. PMID 30044712, Free PMC Article

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Proteolysis of adaptor protein Mmr1 during budding is necessary for mitochondrial homeostasis in Saccharomyces cerevisiae.
    Title: Proteolysis of adaptor protein Mmr1 during budding is necessary for mitochondrial homeostasis in Saccharomyces cerevisiae.
  2. Mmr1p contributes to mitochondrial inheritance as a mediator of anchorage of mitochondria to cER sheets in the yeast bud tip.
    Title: Role for cER and Mmr1p in anchorage of mitochondria at sites of polarized surface growth in budding yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables phospholipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intracellular distribution of mitochondria IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within intracellular distribution of mitochondria IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion inheritance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitochondrion inheritance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular bud IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud tip IEA
Inferred from Electronic Annotation
more info
  
located_in cortical endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in incipient cellular bud site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane HDA PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mmr1p
NP_013291.1
  • Phospholipid binding protein; interacts with mitochondria and with Myo2p, functioning as an adaptor that recruits Myo2p and facilitates actin-based transport of mitochondria to the bud; mediates mitochondria anchorage at the bud tip; phosphorylated protein that localizes to the mitochondrial outer membrane; mRNA is targeted to the bud via the transport system involving She2p; member of the DSL1 family of tethering proteins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    535214..536689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182077.1 → NP_013291.1  TPA: Mmr1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013291.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYJ3, Q06324
    UniProtKB/TrEMBL
    B3RH81, C7GIX7, C8ZDF8, N1NYC9
    Conserved Domains (1) summary
    pfam08505
    Location:60 → 281
    MMR1; Mitochondrial Myo2 receptor-related protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06324.1

Gene LinkOut

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