SWI6 transcriptional regulator SWI6 [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: SWI6
Official Full Name: transcriptional regulator SWI6
Primary source: SGD:S000004172
Locus tag: YLR182W
See related: AllianceGenome:SGD:S000004172; FungiDB:YLR182W; VEuPathDB:YLR182W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PSL8; SDS11
Summary: Enables transcription coactivator activity. Involved in positive regulation of reciprocal meiotic recombination; positive regulation of transcription from RNA polymerase II promoter in response to heat stress; and positive regulation of transcription involved in G1/S transition of mitotic cell cycle. Located in cytoplasm and nucleus. Part of MBF transcription complex and SBF transcription complex. [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See SWI6 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (517940..520351)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Swi4/Swi6 (SBF) factor binding at HO follows a temporal cascade, with SBF bound at upstream regulatory sequence (URS2-L) serving to relay a signal from URS1 to the SBF sites in URS2-R that ultimately activate gene expression.
Title: Spatiotemporal cascade of transcription factor binding required for promoter activation.
study identifies a region of the carboxy terminus of Swi6 that is required for Nrm1 and Whi5 binding to their target transcription factors and show that mutation of this region overrides the repression of MBF- and SBF-regulated genes by Nrm1 and Whi5.
Title: Repression of G1/S transcription is mediated via interaction of the GTB motifs of Nrm1 and Whi5 with Swi6.
We found that the transcriptional cofactor Swi6p and activator Swi4p, as well as the G(2)/M-specific cyclin Clb2p, are required in a microtubule-destabilizing environment
Title: Cell cycle regulators interact with pathways that modulate microtubule stability in Saccharomyces cerevisiae.
oxidative stress signaling for cell cycle regulation occurs through oxidation of the G(1)/S-specific transcription factor Swi6p and consequently leads to suppression of the expression of G(1) cyclins and a delay in cells entering the cell cycle.
Title: Cell cycle sensing of oxidative stress in Saccharomyces cerevisiae by oxidation of a specific cysteine residue in the transcription factor Swi6p.
Data show that in Swi6 the structural and physical features of the nucleic acid binding interface have been completely eradicated.
Title: Structure of the amino-terminal domain from the cell-cycle regulator Swi6.
Data show that Mpk1 negatively regulates Swi6 by phosphorylation on Ser238, which inhibits nuclear entry.
Title: Yeast Mpk1 cell wall integrity mitogen-activated protein kinase regulates nucleocytoplasmic shuttling of the Swi6 transcriptional regulator.
Identified the cell cycle-regulated SBF protein complex(Swi4/Swi6) as required for H3K79 dimethylation.
Title: Linking cell cycle to histone modifications: SBF and H2B monoubiquitination machinery and cell-cycle regulation of H3K79 dimethylation.
Swi6p is involved in oxidant sensing leading to cell division delay.
Title: Oxidant-induced cell-cycle delay in Saccharomyces cerevisiae: the involvement of the SWI6 transcription factor.
propose a model in which phosphorylated Mpk1 or Mlp1 forms a dimeric complex with Swi4 that is competent to associate with the FKS2 promoter
Title: Yeast Mpk1 mitogen-activated protein kinase activates transcription through Swi4/Swi6 by a noncatalytic mechanism that requires upstream signal.
binding of the Swi4/Swi6 (SBF) transcription factors to an evolutionarily conserved site within the recombination enhancer
Title: Cell cycle-dependent regulation of Saccharomyces cerevisiae donor preference during mating-type switching by SBF (Swi4/Swi6) and Fkh1.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of MBF transcription complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MBF transcription complex	IDA Inferred from Direct Assay more info	PubMed
part_of RNA polymerase II transcription regulator complex	IEA Inferred from Electronic Annotation more info
part_of SBF transcription complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SBF transcription complex	IDA Inferred from Direct Assay more info	PubMed
part_of SBF transcription complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of SBF transcription complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: transcriptional regulator SWI6

NP_013283.1

Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

517940..520351

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182069.1 → NP_013283.1 TPA: transcriptional regulator SWI6 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013283.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYI6, P09959

UniProtKB/TrEMBL

G2WJ15, N1NZS2

Conserved Domains (5) summary

PHA03095
Location:308 → 509

PHA03095; ankyrin-like protein; Provisional

COG1196
Location:537 → 773

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

sd00045
Location:317 → 348

ANK; ANK repeat [structural motif]

pfam00023
Location:469 → 501

Ank; Ankyrin repeat

pfam18530
Location:4 → 106

Swi6_N; Swi6 N-terminal domain