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STM1 Stm1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850843, updated on 3-Nov-2024

Summary

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Official Symbol
STM1
Official Full Name
Stm1p
Primary source
SGD:S000004140
Locus tag
YLR150W
See related
AllianceGenome:SGD:S000004140; FungiDB:YLR150W; VEuPathDB:YLR150W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MPT4
Summary
Enables ribosome binding activity; telomeric DNA binding activity; and triplex DNA binding activity. Involved in several processes, including TOR signaling; regulation of translational initiation in response to stress; and translational elongation. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See STM1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (440467..441288)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene tethering complex subunit PEP3 Neighboring gene Gid11p Neighboring gene 8-oxo-dGTP diphosphatase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Saccharomyces cerevisiae protein Stm1p facilitates ribosome preservation during quiescence. Van Dyke N, et al. Biochem Biophys Res Commun, 2013 Jan 11. PMID 23206692
  2. A yeast gene product, G4p2, with a specific affinity for quadruplex nucleic acids. Frantz JD, et al. J Biol Chem, 1995 Apr 21. PMID 7721866
  3. Stm1p, a ribosome-associated protein, is important for protein synthesis in Saccharomyces cerevisiae under nutritional stress conditions. Van Dyke N, et al. J Mol Biol, 2006 May 12. PMID 16580682
  4. Similarity between the association factor of ribosomal subunits and the protein Stm1p from Saccharomyces cerevisiae. Correia H, et al. Mem Inst Oswaldo Cruz, 2004 Nov. PMID 15654430
  5. Location of the triplex DNA-binding domain of Saccharomyces cerevisiae Stm1 protein. Katayama T, et al. Nucleic Acids Symp Ser (Oxf), 2007. PMID 18029617

See all (137) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TORC1 phosphorylates and inhibits the ribosome preservation factor Stm1 to activate dormant ribosomes.
    Title: TORC1 phosphorylates and inhibits the ribosome preservation factor Stm1 to activate dormant ribosomes.
  2. These findings suggest that Stm1p can act as a ribosome preservation factor under conditions of nutrient deprivation and restoration.
    Title: The Saccharomyces cerevisiae protein Stm1p facilitates ribosome preservation during quiescence.
  3. Stm1 may recognize the shape of the triplex rather than the base sequence of the triplex.
    Title: The interaction between the purine motif triplex and the triplex DNA-binding domain of Saccharomyces cerevisiae Stm1 protein.
  4. data indicates that Stm1p plays a complementary role to eEF3 in translation.
    Title: Stm1p alters the ribosome association of eukaryotic elongation factor 3 and affects translation elongation.
  5. Stm1 loss-of-function alleles and overexpression strains show several genetic interactions with Pat1 and Dhh1 alleles in a manner consistent with Stm1 working upstream of Dhh1 to promote Dhh1 function.
    Title: Stm1 modulates mRNA decay and Dhh1 function in Saccharomyces cerevisiae.
  6. Stm(amino acids 1-113) is the minimal domain to specifically bind with the purine motif triplex.
    Title: Location of the triplex DNA-binding domain of Saccharomyces cerevisiae Stm1 protein.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables telomeric DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables triplex DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in TOR signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translational initiation in response to stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in translational elongation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in translational elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Stm1p
NP_013251.1
  • Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    440467..441288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182037.1 → NP_013251.1  TPA: Stm1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013251.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYE5, P39015
    UniProtKB/TrEMBL
    A7A149, B3LTB1, B5VN78, C7GMK2, G2WIY9, N1NZQ8
    Conserved Domains (1) summary
    pfam09598
    Location:3 → 53
    Stm1_N
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39015.3

Gene LinkOut

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