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RFU1 Rfu1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850762, updated on 2-Nov-2024

Summary

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Official Symbol
RFU1
Official Full Name
Rfu1p
Primary source
SGD:S000004063
Locus tag
YLR073C
See related
AllianceGenome:SGD:S000004063; FungiDB:YLR073C; VEuPathDB:YLR073C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables enzyme inhibitor activity. Involved in ubiquitin recycling. Located in endosome. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RFU1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (281019..281621, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Rgr1p Neighboring gene Lam6p Neighboring gene Bud20p Neighboring gene ribosomal 60S subunit protein L10

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The ESCRT-III adaptor protein Bro1 controls functions of regulator for free ubiquitin chains 1 (Rfu1) in ubiquitin homeostasis. Kimura Y, et al. J Biol Chem, 2014 Aug 1. PMID 24962567, Free PMC Article
  2. Conserved Mode of Interaction between Yeast Bro1 Family V Domains and YP(X)nL Motif-Containing Target Proteins. Kimura Y, et al. Eukaryot Cell, 2015 Oct. PMID 26150415, Free PMC Article
  3. An inhibitor of a deubiquitinating enzyme regulates ubiquitin homeostasis. Kimura Y, et al. Cell, 2009 May 1. PMID 19410548
  4. Whi3, a developmental regulator of budding yeast, binds a large set of mRNAs functionally related to the endoplasmic reticulum. Colomina N, et al. J Biol Chem, 2008 Oct 17. PMID 18667435, Free PMC Article
  5. A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking. Aguilar PS, et al. Nat Struct Mol Biol, 2010 Jul. PMID 20526336, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. overexpression of Bro1, particularly the V domain, prevented Rfu1 degradation in response to heat shock
    Title: The ESCRT-III adaptor protein Bro1 controls functions of regulator for free ubiquitin chains 1 (Rfu1) in ubiquitin homeostasis.
  2. identified a protein designated Rfu1 (regulator of free ubiquitin chains 1), which regulates intracellular concentrations of monomeric ubiquitins; functions as an inhibitor of Doa4
    Title: An inhibitor of a deubiquitinating enzyme regulates ubiquitin homeostasis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endosome HDA PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rfu1p
NP_013174.1
  • Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p; GFP-fusion protein localizes to endosomes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    281019..281621 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181960.1 → NP_013174.1  TPA: Rfu1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013174.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A7A0X8, B3LT42, D6VY74, Q08003
    UniProtKB/TrEMBL
    C7GQP8, C8ZD44, G2WIR5, N1NY30
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08003.1

Gene LinkOut

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