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MNL2 putative mannosidase MNL2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850746, updated on 2-Nov-2024

Summary

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Official Symbol
MNL2
Official Full Name
putative mannosidase MNL2
Primary source
SGD:S000004047
Locus tag
YLR057W
See related
AllianceGenome:SGD:S000004047; FungiDB:YLR057W; VEuPathDB:YLR057W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Involved in ERAD pathway. Located in endoplasmic reticulum. Orthologous to human MAN1A1 (mannosidase alpha class 1A member 1); MAN1A2 (mannosidase alpha class 1A member 2); and MAN1C1 (mannosidase alpha class 1C member 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MNL2 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (255306..257855)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene SAGA complex subunit SPT8 Neighboring gene C-5 sterol desaturase Neighboring gene glycine hydroxymethyltransferase SHM2 Neighboring gene Rex2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phenotypic analysis of α1,2-mannosidase-like protein deletion mutants in Saccharomyces cerevisiae. Nakamasu S, et al. MicroPubl Biol, 2022. PMID 36217443, Free PMC Article
  2. Mnl2, a novel component of the ER associated protein degradation pathway. Martinez Benitez E, et al. Biochem Biophys Res Commun, 2011 Oct 28. PMID 21971548
  3. Combining multisource information through functional-annotation-based weighting: gene function prediction in yeast. Ray SS, et al. IEEE Trans Biomed Eng, 2009 Feb. PMID 19272921
  4. Endoplasmic reticulum-associated degradation (ERAD) and free oligosaccharide generation in Saccharomyces cerevisiae. Chantret I, et al. J Biol Chem, 2011 Dec 2. PMID 21979948, Free PMC Article
  5. Synthesis of mannosylinositol phosphorylceramides is involved in maintenance of cell integrity of yeast Saccharomyces cerevisiae. Morimoto Y, et al. Mol Microbiol, 2015 Feb. PMID 25471153

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in ERAD pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative mannosidase MNL2
NP_013158.1
  • Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    255306..257855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181944.1 → NP_013158.1  TPA: putative mannosidase MNL2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013158.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VY59, Q12205, Q7LGY1
    UniProtKB/TrEMBL
    G2WIQ0, N1NZ44
    Conserved Domains (1) summary
    cl04955
    Location:197 → 848
    LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12205.1

Gene LinkOut

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