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FCF2 Fcf2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850740, updated on 1-Aug-2024

Summary

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Gene symbol
FCF2
Gene description
Fcf2p
Primary source
FungiDB:YLR051C
Locus tag
YLR051C
See related
SGD:S000004041; AllianceGenome:SGD:S000004041; VEuPathDB:YLR051C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Orthologous to human DNTTIP2 (deoxynucleotidyltransferase terminal interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See FCF2 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (246324..246977, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Mlo50p Neighboring gene Ema19p Neighboring gene Ies3p Neighboring gene Nrs1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The complete structure of the small-subunit processome. Barandun J, et al. Nat Struct Mol Biol, 2017 Nov. PMID 28945246
  2. Artificial intelligence-assisted cryoEM structure of Bfr2-Lcp5 complex observed in the yeast small subunit processome. Zhao Y, et al. Commun Biol, 2022 Jun 1. PMID 35650250, Free PMC Article
  3. Fcf1p and Fcf2p are novel nucleolar Saccharomyces cerevisiae proteins involved in pre-rRNA processing. Rempola B, et al. Biochem Biophys Res Commun, 2006 Jul 28. PMID 16762320
  4. Nop9 is an RNA binding protein present in pre-40S ribosomes and required for 18S rRNA synthesis in yeast. Thomson E, et al. RNA, 2007 Dec. PMID 17956976, Free PMC Article
  5. Pwp2 mediates UTP-B assembly via two structurally independent domains. Boissier F, et al. Sci Rep, 2017 Jun 9. PMID 28600509, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. localized to the nucleolus; involved in pre-rRNA processing
    Title: Fcf1p and Fcf2p are novel nucleolar Saccharomyces cerevisiae proteins involved in pre-rRNA processing.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleolus HDA PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Fcf2p
NP_013152.1
  • Nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon; essential gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    246324..246977 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181938.1 → NP_013152.1  TPA: Fcf2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013152.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VY53, Q12035
    UniProtKB/TrEMBL
    G2WIP4, N1NZG0
    Conserved Domains (1) summary
    pfam08698
    Location:102 → 190
    Fcf2; Fcf2 pre-rRNA processing
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12035.1

Gene LinkOut

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