AAT2 aspartate transaminase AAT2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: AAT2
Official Full Name: aspartate transaminase AAT2
Primary source: SGD:S000004017
Locus tag: YLR027C
See related: AllianceGenome:SGD:S000004017; FungiDB:YLR027C; VEuPathDB:YLR027C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ASP5
Summary: Enables L-aspartate:2-oxoglutarate aminotransferase activity and ribosomal large subunit binding activity. Involved in aspartate biosynthetic process. Acts upstream of or within negative regulation of translation in response to oxidative stress. Located in cytosol and peroxisome. Human ortholog(s) of this gene implicated in amyloidosis; amyotrophic lateral sclerosis; developmental and epileptic encephalopathy 82; pancreatic ductal adenocarcinoma; and transient cerebral ischemia. Orthologous to several human genes including GOT1 (glutamic-oxaloacetic transaminase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See AAT2 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (196829..198085, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables L-aspartate:2-oxoglutarate aminotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-aspartate:2-oxoglutarate aminotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables L-aspartate:2-oxoglutarate aminotransferase activity	IEA Inferred from Electronic Annotation more info
enables L-aspartate:2-oxoglutarate aminotransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables ribosomal large subunit binding	IDA Inferred from Direct Assay more info	PubMed
enables transaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in aspartate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in aspartate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of translation in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info
located_in peroxisome	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: aspartate transaminase AAT2

NP_013127.2

EC 2.6.1.1

Cytosolic aspartate aminotransferase involved in the metabolism of nitrogen and amino acids such as aspartate; localizes to and functions in peroxisomes in oleate-grown cells; moonlighting role as a ribosome-associated protein that modulates translation in response to stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

196829..198085 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181914.1 → NP_013127.2 TPA: aspartate transaminase AAT2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013127.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VY29, P23542

UniProtKB/TrEMBL

A7A0T3, B3LT00, N1NZ14

Conserved Domains (1) summary

COG1448
Location:5 → 409

TyrB; Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]