YEH2 sterol esterase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: YEH2
Official Full Name: sterol esterase
Primary source: SGD:S000004010
Locus tag: YLR020C
See related: AllianceGenome:SGD:S000004010; FungiDB:YLR020C; VEuPathDB:YLR020C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables sterol esterase activity. Involved in cell wall mannoprotein biosynthetic process and sterol metabolic process. Located in plasma membrane. Is integral component of membrane. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; cholesterol ester storage disease; and lysosomal and lipase deficiency. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPK (lipase family member K). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See YEH2 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (181789..183405, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that the gene product of YEH2/ YLR020c is a steryl ester hydrolase.
Title: YEH2/YLR020c encodes a novel steryl ester hydrolase of the yeast Saccharomyces cerevisiae.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables sterol ester esterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sterol ester esterase activity	IDA Inferred from Direct Assay more info	PubMed
enables sterol ester esterase activity	IEA Inferred from Electronic Annotation more info
enables sterol ester esterase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cell wall mannoprotein biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sterol esterase

NP_013120.1

EC 3.1.1.13

Steryl ester hydrolase; catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism; YEH2 has a paralog, YEH1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

181789..183405 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181907.1 → NP_013120.1 TPA: sterol esterase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013120.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VY22, Q07950

UniProtKB/TrEMBL

A7A0S5, B3LSZ3, C7GXG6, C8ZCZ2, G2WIL4, N1P0E0

Conserved Domains (2) summary

PLN02872
Location:163 → 298

PLN02872; triacylglycerol lipase

cl21494
Location:194 → 435

Abhydrolase; alpha/beta hydrolases