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LOT6 flavin-dependent quinone reductase [ Saccharomyces cerevisiae S288C ]

Gene ID: 850698, updated on 2-Nov-2024

Summary

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Official Symbol
LOT6
Official Full Name
flavin-dependent quinone reductase
Primary source
SGD:S000004001
Locus tag
YLR011W
See related
AllianceGenome:SGD:S000004001; FungiDB:YLR011W; VEuPathDB:YLR011W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables NAD(P)H dehydrogenase (quinone) activity. Involved in apoptotic process and cellular response to oxidative stress. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See LOT6 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (169103..169678)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Ten1p Neighboring gene tRNA-Ser Neighboring gene uncharacterized protein Neighboring gene Gat3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lot6p from Saccharomyces cerevisiae is a FMN-dependent reductase with a potential role in quinone detoxification. Sollner S, et al. FEBS J, 2007 Mar. PMID 17298444
  2. The Saccharomyces cerevisiae quinone oxidoreductase Lot6p: stability, inhibition and cooperativity. Megarity CF, et al. FEMS Yeast Res, 2014 Aug. PMID 24866129
  3. Epoxidation of conjugated C=C-bonds and sulfur-oxidation of thioethers mediated by NADH:FMN-dependent oxidoreductases. Mueller NJ, et al. Org Biomol Chem, 2009 Mar 21. PMID 19262930
  4. The redox-sensing quinone reductase Lot6p acts as an inducer of yeast apoptosis. Sollner S, et al. FEMS Yeast Res, 2009 Sep. PMID 19709309
  5. Mechanism of flavin reduction and oxidation in the redox-sensing quinone reductase Lot6p from Saccharomyces cerevisiae. Sollner S, et al. Biochemistry, 2009 Sep 15. PMID 19618916, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Using hexahistidine tagged, recombinant Lot6p, the authors determined the steady-state enzyme kinetic parameters with both NADH and NADPH as electron donors; no cooperativity was observed with these substrates.
    Title: The Saccharomyces cerevisiae quinone oxidoreductase Lot6p: stability, inhibition and cooperativity.
  2. The authors propose that Lot6p is directly involved in the control of the apoptosis-like cell death in yeast.
    Title: The redox-sensing quinone reductase Lot6p acts as an inducer of yeast apoptosis.
  3. Hydride transfer, and not an enzyme conformational change, is rate-determining in the Lot6 reductive half-reaction. In the oxidative half-reaction, reduced enzyme reacted in a single phase with six quinone substrates tested.
    Title: Mechanism of flavin reduction and oxidation in the redox-sensing quinone reductase Lot6p from Saccharomyces cerevisiae.
  4. Lot6-proteasome complex can be regarded as a redox switch in which the quinone reductase acts as a sensor for oxidative stress
    Title: Quinone reductase acts as a redox switch of the 20S yeast proteasome.
  5. LOT6 is a FMN-dependent reductase with a potential role in quinone detoxification.
    Title: Lot6p from Saccharomyces cerevisiae is a FMN-dependent reductase with a potential role in quinone detoxification.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables FMN binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables FMN reductase (NAD(P)H) activity IEA
Inferred from Electronic Annotation
more info
  
enables FMN reductase (NADH) activity IEA
Inferred from Electronic Annotation
more info
  
enables FMN reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD(P)H dehydrogenase (quinone) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD(P)H dehydrogenase (quinone) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
flavin-dependent quinone reductase
NP_013111.1
  • FMN-dependent NAD(P)H:quinone reductase; role in apoptosis-like cell death; may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    169103..169678
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181898.1 → NP_013111.1  TPA: flavin-dependent quinone reductase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013111.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VY13, Q07923
    UniProtKB/TrEMBL
    A7A0R6, B3LSY4, B5VMV3, C7GXF7, C8ZCY3, G2WIK5, N1P0D3
    Conserved Domains (1) summary
    COG0431
    Location:1 → 189
    SsuE; NAD(P)H-dependent FMN reductase [Energy production and conversion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07923.1

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