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NOC3 Noc3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850688, updated on 2-Nov-2024

Summary

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Official Symbol
NOC3
Official Full Name
Noc3p
Primary source
SGD:S000003992
Locus tag
YLR002C
See related
AllianceGenome:SGD:S000003992; FungiDB:YLR002C; VEuPathDB:YLR002C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables chromatin binding activity. Involved in DNA-templated DNA replication and ribosome biogenesis. Located in nucleolus and nucleoplasm. Part of Noc2p-Noc3p complex and nuclear pre-replicative complex. Orthologous to human NOC3L (NOC3 like DNA replication regulator). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See NOC3 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (154343..156334, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene dynamin-related GTPase DNM1 Neighboring gene uncharacterized protein Neighboring gene Cms1p Neighboring gene Thi73p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Maturation and intranuclear transport of pre-ribosomes requires Noc proteins. Milkereit P, et al. Cell, 2001 May 18. PMID 11371346
  2. The Noc proteins involved in ribosome synthesis and export contain divergent HEAT repeats. Dlakić M, et al. RNA, 2004 Mar. PMID 14970380, Free PMC Article
  3. Noc3p, a bHLH protein, plays an integral role in the initiation of DNA replication in budding yeast. Zhang Y, et al. Cell, 2002 Jun 28. PMID 12110182
  4. The nucle(ol)ar Tif6p and Efl1p are required for a late cytoplasmic step of ribosome synthesis. Senger B, et al. Mol Cell, 2001 Dec. PMID 11779510
  5. A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits. Milkereit P, et al. J Biol Chem, 2003 Feb 7. PMID 12446671

See all (98) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An essential Noc3p dimerization cycle mediates ORC double-hexamer formation in replication licensing.
    Title: An essential Noc3p dimerization cycle mediates ORC double-hexamer formation in replication licensing.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in pre-replicative complex assembly involved in nuclear cell cycle DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Noc2p-Noc3p complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pre-replicative complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Noc3p
NP_013102.1
  • Subunit of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins, and is required for pre-RC formation and maintenance during DNA replication licensing

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    154343..156334 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181889.1 → NP_013102.1  TPA: Noc3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013102.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VY04, Q07896, Q92280
    UniProtKB/TrEMBL
    A7A0Q7, B3LTG7, B5VMU3, C7GPF6, C8ZCX4
    Conserved Domains (1) summary
    COG5117
    Location:1 → 660
    NOC3; Protein involved in the nuclear export of pre-ribosomes [Translation, ribosomal structure and biogenesis / Intracellular trafficking and secretion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07896.1

Gene LinkOut

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