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LDB18 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850677, updated on 11-Sep-2024

Summary

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Official Symbol
LDB18
Primary source
SGD:S000003972
Locus tag
YLL049W
See related
AllianceGenome:SGD:S000003972; FungiDB:YLL049W; VEuPathDB:YLL049W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in establishment of mitotic spindle orientation. Part of dynactin complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (40666..41205)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene putative ferric-chelate reductase Neighboring gene cofilin Neighboring gene bile acid-transporting ATPase YBT1 Neighboring gene Rnp1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A genome-wide screen for Saccharomyces cerevisiae nonessential genes involved in mannosyl phosphate transfer to mannoprotein-linked oligosaccharides. Corbacho I, et al. Fungal Genet Biol, 2005 Sep. PMID 15993632
  2. Dynein-driven mitotic spindle positioning restricted to anaphase by She1p inhibition of dynactin recruitment. Woodruff JB, et al. Mol Biol Cell, 2009 Jul. PMID 19403691, Free PMC Article
  3. Constitutive dynein activity in She1 mutants reveals differences in microtubule attachment at the yeast spindle pole body. Bergman ZJ, et al. Mol Biol Cell, 2012 Jun. PMID 22535527, Free PMC Article
  4. Functional analysis of eight open reading frames on chromosomes XII and XIV of Saccharomyces cerevisiae. Ahmed Khan S, et al. Yeast, 2000 Dec. PMID 11113969
  5. An array of nuclear microtubules reorganizes the budding yeast nucleus during quiescence. Laporte D, et al. J Cell Biol, 2013 Nov 25. PMID 24247429, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in establishment of mitotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of dynactin complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Ldb18p
NP_013051.1
  • Component of the dynactin complex; dynactin is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    40666..41205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181869.1 → NP_013051.1  TPA: Ldb18p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013051.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXV9, Q07887
    UniProtKB/TrEMBL
    B3LTC7, B5VMQ2, C7GNE6, C8ZCS6, N1P116
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07887.1

Gene LinkOut

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