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DRS1 putative ATP-dependent RNA helicase [ Saccharomyces cerevisiae S288C ]

Gene ID: 850652, updated on 2-Nov-2024

Summary

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Official Symbol
DRS1
Official Full Name
putative ATP-dependent RNA helicase
Primary source
SGD:S000003931
Locus tag
YLL008W
See related
AllianceGenome:SGD:S000003931; FungiDB:YLL008W; VEuPathDB:YLL008W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable RNA helicase activity. Involved in rRNA processing and ribosomal large subunit assembly. Located in nucleolus. Part of preribosome, large subunit precursor. Orthologous to human DDX27 (DEAD-box helicase 27). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See DRS1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (131729..133987)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene phosphatase Neighboring gene copper metallochaperone COX17 Neighboring gene Lmo1p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A putative ATP-dependent RNA helicase involved in Saccharomyces cerevisiae ribosome assembly. Ripmaster TL, et al. Proc Natl Acad Sci U S A, 1992 Dec 1. PMID 1454790, Free PMC Article
  2. Saccharomyces cerevisiae nucleolar protein Nop7p is necessary for biogenesis of 60S ribosomal subunits. Adams CC, et al. RNA, 2002 Feb. PMID 11911362, Free PMC Article
  3. DRS1 to DRS7, novel genes required for ribosome assembly and function in Saccharomyces cerevisiae. Ripmaster TL, et al. Mol Cell Biol, 1993 Dec. PMID 8247005, Free PMC Article
  4. Disruption of ribosome assembly in yeast blocks cotranscriptional pre-rRNA processing and affects the global hierarchy of ribosome biogenesis. Talkish J, et al. RNA, 2016 Jun. PMID 27036125, Free PMC Article
  5. Sequence analysis of the CEN12 region of Saccharomyces cerevisiae on a 43.7 kb fragment of chromosome XII including an open reading frame homologous to the human cystic fibrosis transmembrane conductance regulator protein CFTR. Miosga T, et al. Yeast, 1996 Jun 15. PMID 8810043

See all (90) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleolus HDA PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, large subunit precursor IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
putative ATP-dependent RNA helicase
NP_013093.1
  • Nucleolar DEAD-box protein required for ribosome assembly and function; including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    131729..133987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181828.1 → NP_013093.1  TPA: putative ATP-dependent RNA helicase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013093.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A7A0P8, D6VXZ4, P32892
    UniProtKB/TrEMBL
    B3LTF9, B5VMT4
    Conserved Domains (1) summary
    COG0513
    Location:232 → 726
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32892.2

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