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PSR1 phosphatase [ Saccharomyces cerevisiae S288C ]

Gene ID: 850650, updated on 3-Nov-2024

Summary

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Official Symbol
PSR1
Official Full Name
phosphatase
Primary source
SGD:S000003933
Locus tag
YLL010C
See related
AllianceGenome:SGD:S000003933; FungiDB:YLL010C; VEuPathDB:YLL010C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phosphoprotein phosphatase activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of TORC1 signaling; and positive regulation of transcription by RNA polymerase II. Located in plasma membrane. Orthologous to several human genes including CTDSP2 (CTD small phosphatase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PSR1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (129330..130613, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene sterol esterase Neighboring gene rRNA-processing protein SOF1 Neighboring gene copper metallochaperone COX17 Neighboring gene putative ATP-dependent RNA helicase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Improved Acetic Acid Resistance in Saccharomyces cerevisiae by Overexpression of the WHI2 Gene Identified through Inverse Metabolic Engineering. Chen Y, et al. Appl Environ Microbiol, 2016 Jan 29. PMID 26826231, Free PMC Article
  2. Yeast Whi2 and Psr1-phosphatase form a complex and regulate STRE-mediated gene expression. Kaida D, et al. Genes Cells, 2002 Jun. PMID 12090248
  3. Psr1p/Psr2p, two plasma membrane phosphatases with an essential DXDX(T/V) motif required for sodium stress response in yeast. Siniossoglou S, et al. J Biol Chem, 2000 Jun 23. PMID 10777497
  4. The Whi2p-Psr1p/Psr2p complex regulates interference competition and expansion of cells with competitive advantage in yeast colonies. Maršíková J, et al. Proc Natl Acad Sci U S A, 2020 Jun 30. PMID 32541056, Free PMC Article
  5. The TORC1 effector kinase Npr1 fine tunes the inherent activity of the Mep2 ammonium transport protein. Boeckstaens M, et al. Nat Commun, 2014. PMID 24476960

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to amino acid starvation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to amino acid starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to heat IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of TORC1 signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatase
NP_013091.1
  • Plasma membrane-associated protein phosphatase; involved in the general stress response and the inactivating dephosphorylation of Mep2p; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through Msn2p dephosphorylation, and for inhibition of TORC1 in response to limiting amino acids; regulates the sodium ion stress response with Psr2p; member of the HAD family of protein phosphatases

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    129330..130613 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181830.1 → NP_013091.1  TPA: phosphatase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013091.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXZ2, Q07800
    UniProtKB/TrEMBL
    A7A0P6, B3LTF7, C8ZCW3
    Conserved Domains (1) summary
    COG5190
    Location:6 → 427
    FCP1; TFIIF-interacting CTD phosphatase, includes NLI-interacting factor [Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07800.1

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