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HIF1 Hif1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850638, updated on 2-Nov-2024

Summary

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Official Symbol
HIF1
Official Full Name
Hif1p
Primary source
SGD:S000003945
Locus tag
YLL022C
See related
AllianceGenome:SGD:S000003945; FungiDB:YLL022C; VEuPathDB:YLL022C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables histone binding activity. Involved in nucleosome assembly and subtelomeric heterochromatin formation. Located in nucleus. Part of histone acetyltransferase complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See HIF1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (99044..100201, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Hsp70 family chaperone SSA2 Neighboring gene nucleoporin POM33 Neighboring gene Spa2p Neighboring gene serine/threonine protein kinase KNS1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The yeast histone chaperone hif1p functions with RNA in nucleosome assembly. Knapp AR, et al. PLoS One, 2014. PMID 25072697, Free PMC Article
  2. The nuclear Hat1p/Hat2p complex: a molecular link between type B histone acetyltransferases and chromatin assembly. Ai X, et al. Mol Cell, 2004 Apr 23. PMID 15099519
  3. Recruitment of the type B histone acetyltransferase Hat1p to chromatin is linked to DNA double-strand breaks. Qin S, et al. Mol Cell Biol, 2006 May. PMID 16612003, Free PMC Article
  4. Nuclear Hat1p complex (NuB4) components participate in DNA repair-linked chromatin reassembly. Ge Z, et al. J Biol Chem, 2011 May 13. PMID 21454479, Free PMC Article
  5. Hif1 is a component of yeast histone acetyltransferase B, a complex mainly localized in the nucleus. Poveda A, et al. J Biol Chem, 2004 Apr 16. PMID 14761951

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Report shows that the histone chaperone Hif1, known to interact with histones H3-H4, is also a specific chaperone for the H2A-H2B dimer. The complex structure reveals that Hif1 utilizes different mechanisms for binding H2A-H2B and H3-H4, with implications for the mechanisms underlying nucleosome assembly.
    Title: Structural Insights into the Association of Hif1 with Histones H2A-H2B Dimer and H3-H4 Tetramer.
  2. Hif1 consists of a superhelixed TPR (tetratricopeptide repeat) domain and an extended acid loop covering rear of TPR domain, which represent typical characteristics of SHNi-TPR [Sim3 (start independent of mitosis 3)-Hif1-NASP interrupted TPR] proteins.
    Title: Structural insights into yeast histone chaperone Hif1: a scaffold protein recruiting protein complexes to core histones.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleosome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in subtelomeric heterochromatin formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
part_of histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of histone acetyltransferase complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of histone acetyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Hif1p
NP_013078.1
  • Non-essential component of the HAT-B histone acetyltransferase complex; localized to the nucleus; has a role in telomeric silencing; other members are Hat1p and Hat2p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    99044..100201 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181842.1 → NP_013078.1  TPA: Hif1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013078.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXY2, Q12373
    UniProtKB/TrEMBL
    C7GPH7
    Conserved Domains (1) summary
    pfam10516
    Location:237 → 273
    SHNi-TPR
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12373.1

Gene LinkOut

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