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HXK1 hexokinase 1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850614, updated on 14-Nov-2024

Summary

Official Symbol
HXK1
Official Full Name
hexokinase 1
Primary source
SGD:S000001949
Locus tag
YFR053C
See related
AllianceGenome:SGD:S000001949; FungiDB:YFR053C; VEuPathDB:YFR053C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables hexokinase activity. Involved in glycolytic process; hexose metabolic process; and hexose transmembrane transport. Located in mitochondrion. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 4G; anemia (multiple); artery disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Orthologous to several human genes including GCK (glucokinase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See HXK1 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (253592..255049, complement)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene coatomer subunit delta Neighboring gene proteasome regulatory particle lid subunit RPN12 Neighboring gene uncharacterized protein Neighboring gene cysteine-S-conjugate beta-lyase IRC7

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables D-glucose binding IEA
Inferred from Electronic Annotation
more info
 
enables fructokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fructokinase activity IEA
Inferred from Electronic Annotation
more info
 
enables glucokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glucokinase activity IEA
Inferred from Electronic Annotation
more info
 
enables hexokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hexokinase activity IEA
Inferred from Electronic Annotation
more info
 
enables hexokinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables mannokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in D-glucose import IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in fructose import across plasma membrane IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in fructose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glycolytic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
 
involved_in hexose metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in mannose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mannose metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
hexokinase 1
NP_116711.3
  • Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    253592..255049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180018.3NP_116711.3  TPA: hexokinase 1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116711.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTT6, P04806
    UniProtKB/TrEMBL
    C7GYF6, G4XS65, N1P4S9
    Conserved Domains (1) summary
    COG5026
    Location:6477
    COG5026; Hexokinase [Carbohydrate transport and metabolism]