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CNN1 centromere-binding protein CNN1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850607, updated on 2-Nov-2024

Summary

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Official Symbol
CNN1
Official Full Name
centromere-binding protein CNN1
Primary source
SGD:S000001942
Locus tag
YFR046C
See related
AllianceGenome:SGD:S000001942; FungiDB:YFR046C; VEuPathDB:YFR046C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables centromeric DNA binding activity. Involved in chromosome segregation and negative regulation of kinetochore assembly. Located in kinetochore. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CNN1 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (243074..244159, complement)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene metallodipeptidase Neighboring gene Mrx20p Neighboring gene nicotinate-nucleotide diphosphorylase (carboxylating) Neighboring gene Rmd8p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Mps1 kinase modulates the recruitment and activity of Cnn1(CENP-T) at Saccharomyces cerevisiae kinetochores. Thapa KS, et al. Genetics, 2015 May. PMID 25716979, Free PMC Article
  2. Crystal structure of the Cenp-HIKHead-TW sub-module of the inner kinetochore CCAN complex. Zhang Z, et al. Nucleic Acids Res, 2020 Nov 4. PMID 32976599, Free PMC Article
  3. Multi-site phosphorylation of yeast Mif2/CENP-C promotes inner kinetochore assembly. Hinshaw SM, et al. Curr Biol, 2023 Feb 27. PMID 36736323, Free PMC Article
  4. Cdk1 regulates centrosome separation by restraining proteolysis of microtubule-associated proteins. Crasta K, et al. EMBO J, 2006 Jun 7. PMID 16688214, Free PMC Article
  5. A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors. Malvezzi F, et al. EMBO J, 2013 Feb 6. PMID 23334295, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphorylation of the Cnn1 N-terminus coordinates the binding of the two competing Ndc80 interaction partners.
    Title: A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors.
  2. Cnn1 regulates KMN activity in a spatiotemporal manner by inhibiting the interaction between its complexes
    Title: Cnn1 inhibits the interactions between the KMN complexes of the yeast kinetochore.
  3. Data show that cells that fail to activate Cdk1 are devoid of spindles due to persistently active APCCdh1, which targets microtubule-associated proteins Cin8, Kip1 and Ase1 for degradation.
    Title: Cdk1 regulates centrosome separation by restraining proteolysis of microtubule-associated proteins.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables centromeric DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in negative regulation of kinetochore assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
centromere-binding protein CNN1
NP_116704.1
  • Kinetochore protein; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by Clb5-Cdk1, Mps1p, Ipl1p and to a lesser extent by Clb2-Cdk1; localizes to the lower region of the Ndc80 complex during anaphase and regulates KMN activity by inhibiting the Mtw1 and Spc105 complexes from binding to the Ndc80 complex; similar to metazoan CENP-T

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    243074..244159 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180011.1 → NP_116704.1  TPA: centromere-binding protein CNN1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116704.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTS9, P43618, Q6B2K8
    UniProtKB/TrEMBL
    A7A286, B3LUQ7, B5VI71, C7GYE9, C8Z7Y1, G2WDI7, N1P4F6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43618.1

Gene LinkOut

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