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CDC26 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850597, updated on 11-Sep-2024

Summary

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Official Symbol
CDC26
Primary source
SGD:S000001932
Locus tag
YFR036W
See related
AllianceGenome:SGD:S000001932; FungiDB:YFR036W; VEuPathDB:YFR036W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HIT3; SCD26
Summary
Contributes to ubiquitin protein ligase activity. Involved in anaphase-promoting complex-dependent catabolic process; chromatin assembly; and protein ubiquitination. Located in cytosol and nucleus. Part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (226963..227337)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tRNA-Lys Neighboring gene Rsc8p Neighboring gene putative ATPase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The CDC26 gene of Saccharomyces cerevisiae is required for cell growth only at high temperature. Araki H, et al. Mol Gen Genet, 1992 Jan. PMID 1736102
  2. Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC6 structure. Wang J, et al. Nat Struct Mol Biol, 2009 Sep. PMID 19668213, Free PMC Article
  3. The ubiquitin-dependent targeting pathway in Saccharomyces cerevisiae plays a critical role in multiple chromatin assembly regulatory steps. Harkness TA, et al. Genetics, 2002 Oct. PMID 12399376, Free PMC Article
  4. Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae. Zachariae W, et al. Science, 1996 Nov 15. PMID 8895471
  5. A novel yeast screen for mitotic arrest mutants identifies DOC1, a new gene involved in cyclin proteolysis. Hwang LH, et al. Mol Biol Cell, 1997 Oct. PMID 9348530, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in anaphase-promoting complex-dependent catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of anaphase-promoting complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of anaphase-promoting complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
anaphase promoting complex subunit CDC26
NP_116694.1
  • Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; relocalizes to the cytosol in response to hypoxia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    226963..227337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180001.1 → NP_116694.1  TPA: anaphase promoting complex subunit CDC26 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116694.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTR9, P14724
    UniProtKB/TrEMBL
    A7A276, B3LUP7, C7GYE0, C8Z7X2, G2WDH7, N1P4R4
    Conserved Domains (1) summary
    pfam10471
    Location:1 → 59
    ANAPC_CDC26; Anaphase-promoting complex APC subunit CDC26
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P14724.2

Gene LinkOut

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