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LPD1 dihydrolipoyl dehydrogenase [ Saccharomyces cerevisiae S288C ]

Gene ID: 850527, updated on 3-Nov-2024

Summary

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Official Symbol
LPD1
Official Full Name
dihydrolipoyl dehydrogenase
Primary source
SGD:S000001876
Locus tag
YFL018C
See related
AllianceGenome:SGD:S000001876; FungiDB:YFL018C; VEuPathDB:YFL018C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HPD1
Summary
Enables dihydrolipoyl dehydrogenase activity; glycine dehydrogenase (decarboxylating) activity; and oxidoreductase activity, acting on the aldehyde or oxo group of donors. Involved in carboxylic acid metabolic process; cellular respiration; and hydrogen peroxide metabolic process. Located in mitochondrial nucleoid. Part of glycine cleavage complex; oxoglutarate dehydrogenase complex; and pyruvate dehydrogenase complex. Is active in mitochondrion. Used to study disease of metabolism. Human ortholog(s) of this gene implicated in maple syrup urine disease. Orthologous to human DLD (dihydrolipoamide dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See LPD1 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (101628..103127, complement)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tRNA-Pro Neighboring gene mRNA splicing protein SMX2 Neighboring gene glucosamine 6-phosphate N-acetyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The radial diffusion assay of lipoamide dehydrogenase. Shih JC. Methods Enzymol, 1979. PMID 374971
  2. 3D electron microscopy reveals the variable deposition and protein dynamics of the peripheral pyruvate dehydrogenase component about the core. Gu Y, et al. Proc Natl Acad Sci U S A, 2003 Jun 10. PMID 12756305, Free PMC Article
  3. Increased isobutanol production in Saccharomyces cerevisiae by eliminating competing pathways and resolving cofactor imbalance. Matsuda F, et al. Microb Cell Fact, 2013 Dec 5. PMID 24305546, Free PMC Article
  4. The catabolism of branched-chain amino acids occurs via 2-oxoacid dehydrogenase in Saccharomyces cerevisiae. Dickinson JR, et al. J Gen Microbiol, 1992 Oct. PMID 1479341
  5. A 3' transcriptional enhancer within the coding sequence of a yeast gene encoding the common subunit of two multi-enzyme complexes. Zaman Z, et al. Mol Microbiol, 1992 Jan. PMID 1545708

See all (127) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables dihydrolipoyl dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dihydrolipoyl dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dihydrolipoyl dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydrolipoyl dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables glycine dehydrogenase (decarboxylating) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxoglutarate dehydrogenase (succinyl-transferring) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables pyruvate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in 2-oxoglutarate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 2-oxoglutarate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in L-leucine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in L-serine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hydrogen peroxide metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in hydrogen peroxide metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in isoleucine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pyruvate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyruvate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in valine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of glycine cleavage complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion HDA PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of oxoglutarate dehydrogenase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of oxoglutarate dehydrogenase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of pyruvate dehydrogenase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dihydrolipoyl dehydrogenase
NP_116635.1
  • Dihydrolipoamide dehydrogenase; the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes; PDH complex is concentrated in spots within the mitochondrial matrix, often near the ERMES complex and near peroxisomes; LPD1 has a paralog, IRC15, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    101628..103127 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179948.1 → NP_116635.1  TPA: dihydrolipoyl dehydrogenase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116635.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTL1, P09624
    UniProtKB/TrEMBL
    A7A220, B3LUJ0, B5VI12, G2WDC2, N1P4X6
    Conserved Domains (1) summary
    cl39093
    Location:24 → 498
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09624.1

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