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CAF16 putative ATP-binding cassette family ATPase CAF16 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850516, updated on 18-Sep-2024

Summary

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Official Symbol
CAF16
Official Full Name
putative ATP-binding cassette family ATPase CAF16
Primary source
SGD:S000001866
Locus tag
YFL028C
See related
AllianceGenome:SGD:S000001866; FungiDB:YFL028C; VEuPathDB:YFL028C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable ATP hydrolysis activity. Involved in regulation of transcription by RNA polymerase II. Located in cytoplasm. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CAF16 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (79344..80213, complement)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene alanine--glyoxylate transaminase Neighboring gene cyclin-dependent protein kinase-activating kinase CAK1 Neighboring gene GTPase-activating protein GYP8 Neighboring gene alpha-factor pheromone receptor STE2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Inventory and function of yeast ABC proteins: about sex, stress, pleiotropic drug and heavy metal resistance. Bauer BE, et al. Biochim Biophys Acta, 1999 Dec 6. PMID 10581358
  2. Systematic mutagenesis of the leucine-rich repeat (LRR) domain of CCR4 reveals specific sites for binding to CAF1 and a separate critical role for the LRR in CCR4 deadenylase activity. Clark LB, et al. J Biol Chem, 2004 Apr 2. PMID 14734555
  3. Characterization of CAF4 and CAF16 reveals a functional connection between the CCR4-NOT complex and a subset of SRB proteins of the RNA polymerase II holoenzyme. Liu HY, et al. J Biol Chem, 2001 Mar 9. PMID 11113136
  4. DNA damage and replication stress induced transcription of RNR genes is dependent on the Ccr4-Not complex. Mulder KW, et al. Nucleic Acids Res, 2005. PMID 16275785, Free PMC Article
  5. Ccr4-not regulates RNA polymerase I transcription and couples nutrient signaling to the control of ribosomal RNA biogenesis. Laribee RN, et al. PLoS Genet, 2015 Mar. PMID 25815716, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of CCR4-NOT complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CCR4-NOT complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative ATP-binding cassette family ATPase CAF16
NP_116625.1
  • Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    79344..80213 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179938.1 → NP_116625.1  TPA: putative ATP-binding cassette family ATPase CAF16 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116625.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTK2, P43569
    UniProtKB/TrEMBL
    B3LUI3, B5VI01, C7GY83, C8Z7Q5, G2WDB3, N1P6P1
    Conserved Domains (1) summary
    COG4586
    Location:1 → 289
    COG4586; ABC-type uncharacterized transport system, ATPase component [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43569.1

Gene LinkOut

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