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FET5 ferroxidase FET5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850502, updated on 2-Nov-2024

Summary

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Official Symbol
FET5
Official Full Name
ferroxidase FET5
Primary source
SGD:S000001853
Locus tag
YFL041W
See related
AllianceGenome:SGD:S000001853; FungiDB:YFL041W; VEuPathDB:YFL041W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ferroxidase activity. Involved in iron ion transport. Located in fungal-type vacuole membrane and membrane raft. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See FET5 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (49139..51007)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Lam5p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene actin

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequencing of an 18.8 kb fragment from Saccharomyces cerevisiae chromosome VI. Naitou M, et al. Yeast, 1995 Dec. PMID 8750241
  2. The iron transporter Fth1p forms a complex with the Fet5 iron oxidase and resides on the vacuolar membrane. Urbanowski JL, et al. J Biol Chem, 1999 Dec 31. PMID 10608875
  3. The yeast FET5 gene encodes a FET3-related multicopper oxidase implicated in iron transport. Spizzo T, et al. Mol Gen Genet, 1997 Nov. PMID 9413439
  4. Functional studies of hephaestin in yeast: evidence for multicopper oxidase activity in the endocytic pathway. Li L, et al. Biochem J, 2003 Nov 1. PMID 12921533, Free PMC Article
  5. Assembly, activation, and trafficking of the Fet3p.Ftr1p high affinity iron permease complex in Saccharomyces cerevisiae. Singh A, et al. J Biol Chem, 2006 May 12. PMID 16522632

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ferroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferroxidase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to iron ion starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in iron ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in reductive iron assimilation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ferroxidase FET5
NP_116612.1
  • Multicopper oxidase; integral membrane protein with similarity to Fet3p; targeted to vacuole via AP-3 pathway; may have role in iron transport

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    49139..51007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179925.1 → NP_116612.1  TPA: ferroxidase FET5 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116612.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTI9, P43561
    UniProtKB/TrEMBL
    A7A1Z8, G2WDA0, N1P4H8
    Conserved Domains (1) summary
    COG2132
    Location:1 → 515
    SufI; Multicopper oxidase with three cupredoxin domains (includes cell division protein FtsP and spore coat protein CotA) [Cell cycle control, cell division, chromosome partitioning, Inorganic ion transport and metabolism, Cell wall/membrane/envelope biogenes
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43561.1

Gene LinkOut

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