U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

FMP32 Fmp32p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850498, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
FMP32
Official Full Name
Fmp32p
Primary source
SGD:S000001848
Locus tag
YFL046W
See related
AllianceGenome:SGD:S000001848; FungiDB:YFL046W; VEuPathDB:YFL046W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PUT6
Summary
Involved in mitochondrial cytochrome c oxidase assembly and regulation of proline metabolic process. Located in mitochondrion. Is active in mitochondrial inner membrane. Orthologous to several human genes including CCDC90B (coiled-coil domain containing 90B). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See FMP32 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (42815..43438)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Emp47p Neighboring gene GTPase-activating protein RGD2 Neighboring gene phosphomannomutase SEC53 Neighboring gene ubiquitin-specific protease OTU1

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Functional analysis of coiled-coil domains of MCU in mitochondrial calcium uptake. Yamamoto T, et al. Biochim Biophys Acta Bioenerg, 2019 Dec 1. PMID 31394096
  2. Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism. Zulkifli M, et al. Nat Commun, 2020 Sep 25. PMID 32978391, Free PMC Article
  3. A yeast homolog of chromatin assembly factor 1 is involved in early ribosome assembly. Schaper S, et al. Curr Biol, 2001 Nov 27. PMID 11728313
  4. CCDC90A (MCUR1) is a cytochrome c oxidase assembly factor and not a regulator of the mitochondrial calcium uniporter. Paupe V, et al. Cell Metab, 2015 Jan 6. PMID 25565209
  5. Bipartite signals mediate subcellular targeting of tail-anchored membrane proteins in Saccharomyces cerevisiae. Beilharz T, et al. J Biol Chem, 2003 Mar 7. PMID 12514182

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitochondrial cytochrome c oxidase assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial cytochrome c oxidase assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of proline metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Fmp32p
NP_116608.1
  • Regulator of mitochondrial proline metabolism; tethered with Put7p to inner mitochondrial membrane in large hetero-oligomeric complex, abundance of which is regulated by proline; involved in mitochondrial proline homeostasis and cellular redox balance; null exhibits pronounced defect in proline utilization, and can be functionally complemented by expression of human homolog MCUR1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    42815..43438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179921.1 → NP_116608.1  TPA: Fmp32p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116608.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTI4, P43557
    UniProtKB/TrEMBL
    A7A1Z3, B3LUG5, B5VHY1, C7GY68, C8Z7N6, G2WD95, N1P6K3
    Conserved Domains (1) summary
    pfam07798
    Location:32 → 205
    DUF1640; Protein of unknown function (DUF1640)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43557.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools