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CDC39 CCR4-NOT core subunit CDC39 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850455, updated on 3-Nov-2024

Summary

Official Symbol
CDC39
Official Full Name
CCR4-NOT core subunit CDC39
Primary source
SGD:S000000689
Locus tag
YCR093W
See related
AllianceGenome:SGD:S000000689; FungiDB:YCR093W; VEuPathDB:YCR093W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NOT1; ROS1; SMD6
Summary
Enables ATPase activator activity. Involved in several processes, including negative regulation of cytoplasmic mRNA processing body assembly; positive regulation of RNA metabolic process; and pseudohyphal growth. Located in cytoplasm and nucleus. Part of CCR4-NOT core complex. Human ortholog(s) of this gene implicated in Vissers-Bodmer syndrome and holoprosencephaly 12. Orthologous to human CNOT1 (CCR4-NOT transcription complex subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See CDC39 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (280117..286443)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene putative serine/threonine protein kinase KIN82 Neighboring gene mismatch repair protein MSH3 Neighboring gene aminophospholipid translocase regulatory protein CDC50 Neighboring gene Oca4p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in negative regulation of cytoplasmic mRNA processing body assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cytoplasmic mRNA processing body assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear-transcribed mRNA poly(A) tail shortening IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in pseudohyphal growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in response to pheromone triggering conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transcription elongation by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in transcription elongation by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of CCR4-NOT core complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of CCR4-NOT core complex IEA
Inferred from Electronic Annotation
more info
 
part_of CCR4-NOT core complex IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CCR4-NOT core subunit CDC39
NP_010017.2
  • Subunit of the CCR4-NOT1 core complex; this complex has multiple roles in the regulation of mRNA levels including regulation of transcription and destabilization of mRNA by deadenylation; basal transcription factor that increases initiation and elongation; activates the ATPase activity of Dhh1p, resulting in processing body disassembly

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    280117..286443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178799.1NP_010017.2  TPA: CCR4-NOT core subunit CDC39 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010017.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR93, P25655
    UniProtKB/TrEMBL
    A6ZTR4
    Conserved Domains (1) summary
    COG5103
    Location:12108
    CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]