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SRB8 Srb8p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850442, updated on 3-Nov-2024

Summary

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Official Symbol
SRB8
Official Full Name
Srb8p
Primary source
SGD:S000000677
Locus tag
YCR081W
See related
AllianceGenome:SGD:S000000677; FungiDB:YCR081W; VEuPathDB:YCR081W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GIG1; MED12; NUT6; SSN5; YCR080W
Summary
Enables transcription coactivator activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; and positive regulation of transcription by galactose. Part of mediator complex. Human ortholog(s) of this gene implicated in FG syndrome; leiomyosarcoma; major depressive disorder; phobic disorder; and syndromic X-linked intellectual disorder Lujan-Fryns-type. Orthologous to human MED12 (mediator complex subunit 12) and MED12L (mediator complex subunit 12L). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SRB8 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (254371..258654)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Pat1p Neighboring gene type 2C protein phosphatase PTC6 Neighboring gene Ahc2p Neighboring gene Trx3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Three subunits of the RNA polymerase II mediator complex are involved in glucose repression. Balciunas D, et al. Nucleic Acids Res, 1995 Nov 11. PMID 7501465, Free PMC Article
  2. Mediator expression profiling epistasis reveals a signal transduction pathway with antagonistic submodules and highly specific downstream targets. van de Peppel J, et al. Mol Cell, 2005 Aug 19. PMID 16109375
  3. Mediator subunit Gal11p/MED15 is required for fatty acid-dependent gene activation by yeast transcription factor Oaf1p. Thakur JK, et al. J Biol Chem, 2009 Feb 13. PMID 19056732, Free PMC Article
  4. Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module. Li YC, et al. Sci Adv, 2021 Jan. PMID 33523904, Free PMC Article
  5. A complex of the Srb8, -9, -10, and -11 transcriptional regulatory proteins from yeast. Borggrefe T, et al. J Biol Chem, 2002 Nov 15. PMID 12200444

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Srb8-Srb11 associates with the GAL1 promoter subsequent to SAGA binding, and the binding of TBP and Srb8-Srb11 is interdependent
    Title: The Saccharomyces cerevisiae Srb8-Srb11 complex functions with the SAGA complex during Gal4-activated transcription.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by galactose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Srb8p
NP_010004.1
  • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    254371..258654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178787.1 → NP_010004.1  TPA: Srb8p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010004.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR82, P25647, P25648
    UniProtKB/TrEMBL
    G2WA89
    Conserved Domains (1) summary
    pfam09497
    Location:113 → 175
    Med12; Transcription mediator complex subunit Med12
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25648.2

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