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ARE1 sterol acyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 850415, updated on 2-Nov-2024

Summary

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Official Symbol
ARE1
Official Full Name
sterol acyltransferase
Primary source
SGD:S000000644
Locus tag
YCR048W
See related
AllianceGenome:SGD:S000000644; FungiDB:YCR048W; VEuPathDB:YCR048W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SAT2
Summary
Enables ergosterol O-acyltransferase activity and lanosterol O-acyltransferase activity. Involved in sterol metabolic process. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Chagas disease; cardiomyopathy; and congenital diarrhea 7 with exudative enteropathy. Orthologous to human DGAT1 (diacylglycerol O-acyltransferase 1) and SOAT1 (sterol O-acyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ARE1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (211929..213761)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein IMG1 Neighboring gene 18S rRNA (guanine1575-N7)-methyltransferase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rsc6p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ergosterol O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ergosterol O-acyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables lanosterol O-acyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables lanosterol O-acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in ergosterol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sterol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sterol acyltransferase
NP_009978.1
  • Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    211929..213761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178762.1 → NP_009978.1  TPA: sterol acyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009978.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR57, P25628
    UniProtKB/TrEMBL
    B3LUB3, C8Z4E1
    Conserved Domains (1) summary
    COG5056
    Location:96 → 610
    ARE1; Acyl-CoA cholesterol acyltransferase [Lipid metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25628.1

Gene LinkOut

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